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208 entries « 1 of 5 »

2024

Ondrisova, Laura; Seda, Vaclav; Hlavac, Krystof; Pavelkova, Petra; Hoferkova, Eva; Chiodin, Giorgia; Kostalova, Lenka; Pavlasova, Gabriela Mladonicka; Filip, Daniel; Vecera, Josef; Zeni, Pedro Faria; Oppelt, Jan; Kahounova, Zuzana; Vichova, Rachel; Soucek, Karel; Panovska, Anna; Plevova, Karla; Pospisilova, Sarka; Simkovic, Martin; Vrbacky, Filip; Lysak, Daniel; Fernandes, Stacey M.; Davids, Matthew S.; Maiques-Diaz, Alba; Charalampopoulou, Stella; Martin-Subero, Jose I.; Brown, Jennifer R.; Doubek, Michael; Forconi, Francesco; Mayer, Jiri; Mraz, Marek

FoxO1/Rictor axis induces a non-genetic adaptation to Ibrutinib via Akt activation in chronic lymphocytic leukemia. Journal Article

In: The Journal of clinical investigation, pp. e173770, 2024, ISSN: 1558-8238 0021-9738, (Place: United States).

Abstract | Links | BibTeX | Tags: Drug therapy, Hematology, Leukemias, Oncology, Signal Transduction

Valcikova, Barbora; Vadovicova, Natalia; Smolkova, Karolina; Zacpalova, Magdalena; Krejci, Pavel; Lee, Shannon; Rauch, Jens; Kolch, Walter; Kriegsheim, Alexander; Dorotikova, Anna; Andrysik, Zdenek; Vichova, Rachel; Vacek, Ondrej; Soucek, Karel; Uldrijan, Stjepan

eIF4F controls ERK MAPK signaling in melanomas with BRAF and NRAS mutations. Journal Article

In: Proceedings of the National Academy of Sciences of the United States of America, vol. 121, no. 44, pp. e2321305121, 2024, ISSN: 1091-6490 0027-8424, (Place: United States).

Abstract | Links | BibTeX | Tags: *Eukaryotic Initiation Factor-4F/metabolism/genetics, *GTP Phosphohydrolases/metabolism/genetics, *MAP Kinase Signaling System/genetics, *Melanoma/genetics/metabolism/pathology, *Membrane Proteins/metabolism/genetics, *Mutation, *Proto-Oncogene Proteins B-raf/genetics/metabolism, Animals, Cell Line, Dual Specificity Phosphatase 6/metabolism/genetics, DUSP6, eIF4F, ERK, Extracellular Signal-Regulated MAP Kinases/metabolism, Humans, MAP kinase, Melanoma, Mice, Tumor

Procházková, Jiřina; Fedr, Radek; Hradilová, Barbora; Kvokačková, Barbora; Slavík, Josef; Kováč, Ondrej; Machala, Miroslav; Fabian, Pavel; Navrátil, Jiří; Kráčalíková, Simona; Levková, Monika; Ovesná, Petra; Bouchal, Jan; Souček, Karel

Single-cell profiling of surface glycosphingolipids opens a new dimension for deconvolution of breast cancer intratumoral heterogeneity and phenotypic plasticity. Journal Article

In: Journal of lipid research, vol. 65, no. 9, pp. 100609, 2024, ISSN: 1539-7262 0022-2275, (Place: United States).

Abstract | Links | BibTeX | Tags: *Breast Neoplasms/metabolism/pathology, *Epithelial-Mesenchymal Transition, *Glycosphingolipids/metabolism/analysis, *Single-Cell Analysis/methods, Breast cancer, Epithelial Cells, Female, Glycosphingolipids, Humans, Phenotype, phenotypic plasticity, stromal-like cells, surface profiling

Besse, Andrej; Sedlarikova, Lenka; Buechler, Lorina; Kraus, Marianne; Yang, Chieh-Hsiang; Strakova, Nicol; Soucek, Karel; Navratil, Jiri; Svoboda, Marek; Welm, Alana L.; Joerger, Markus; Driessen, Christoph; Besse, Lenka

HIV-protease inhibitors potentiate the activity of carfilzomib in triple-negative breast cancer. Journal Article

In: British journal of cancer, vol. 131, no. 5, pp. 918–930, 2024, ISSN: 1532-1827 0007-0920, (Place: England).

Abstract | Links | BibTeX | Tags: *ATP Binding Cassette Transporter, *Bortezomib/pharmacology, *Drug Synergism, *HIV Protease Inhibitors/pharmacology, *Lopinavir/pharmacology, *Nelfinavir/pharmacology, *Oligopeptides/pharmacology, *Triple Negative Breast Neoplasms/drug therapy/pathology, *Unfolded Protein Response/drug effects, Antineoplastic Combined Chemotherapy Protocols/pharmacology, Apoptosis/drug effects, ATP Binding Cassette Transporter, Cell Line, Endoplasmic Reticulum Stress/drug effects, Female, Humans, Member 2/metabolism/antagonists & inhibitors, Neoplasm Proteins/antagonists & inhibitors/metabolism, Proteasome Inhibitors/pharmacology, Subfamily B/metabolism, Subfamily G, Tumor, X-Box Binding Protein 1/metabolism/genetics

Drápela, Stanislav; Kvokačková, Barbora; Slabáková, Eva; Kotrbová, Anna; Gömöryová, Kristína; Fedr, Radek; Kurfürstová, Daniela; Eliáš, Martin; Študent, Vladimír Jr; Lenčéšová, Frederika; Ranjani, Ganji Sri; Pospíchalová, Vendula; Bryja, Vítězslav; Weerden, Wytske M.; Puhr, Martin; Culig, Zoran; Bouchal, Jan; Souček, Karel

Pre-existing cell subpopulations in primary prostate cancer tumors display surface fingerprints of docetaxel-resistant cells. Journal Article

In: Cellular oncology (Dordrecht, Netherlands), 2024, ISSN: 2211-3436 2211-3428, (Place: Netherlands).

Abstract | Links | BibTeX | Tags: CD95/Fas, Docetaxel resistance, Intratumoral heterogeneity, Plasticity, Prostate cancer, SSEA-4

Němec, Václav; Remeš, Marek; Beňovský, Petr; Böck, Michael C.; Šranková, Eliška; Wong, Jong Fu; Cros, Julien; Williams, Eleanor; Tse, Lap Hang; Smil, David; Ensan, Deeba; Isaac, Methvin B.; Al-Awar, Rima; Gomolková, Regina; Ursachi, Vlad-Constantin; Fafílek, Bohumil; Kahounová, Zuzana; Víchová, Ráchel; Vacek, Ondřej; Berger, Benedict-Tilman; Wells, Carrow I.; Corona, Cesear R.; Vasta, James D.; Robers, Matthew B.; Krejci, Pavel; Souček, Karel; Bullock, Alex N.; Knapp, Stefan; Paruch, Kamil

Discovery of Two Highly Selective Structurally Orthogonal Chemical Probes for Activin Receptor-like Kinases 1 and 2. Journal Article

In: Journal of medicinal chemistry, vol. 67, no. 15, pp. 12632–12659, 2024, ISSN: 1520-4804 0022-2623, (Place: United States).

Abstract | Links | BibTeX | Tags: *Activin Receptors, Activin Receptors, Animals, Bone Morphogenetic Proteins/metabolism, Drug Discovery, Humans, Mice, Molecular Probes/chemistry, Protein Kinase Inhibitors/pharmacology/chemistry, Pyrazoles/chemistry/pharmacology/chemical synthesis, Signal Transduction/drug effects, Structure-Activity Relationship, Type I/antagonists & inhibitors/metabolism, Type II/metabolism/antagonists & inhibitors

Kahounová, Zuzana; Pícková, Markéta; Drápela, Stanislav; Bouchal, Jan; Szczyrbová, Eva; Navrátil, Jiří; Souček, Karel

Correction: Circulating tumor cell-derived preclinical models: current status and future perspectives. Journal Article

In: Cell death & disease, vol. 15, no. 7, pp. 472, 2024, ISSN: 2041-4889, (Place: England).

Links | BibTeX | Tags:

Pícková, Markéta; Kahounová, Zuzana; Radaszkiewicz, Tomasz; Procházková, Jiřina; Fedr, Radek; Nosková, Michaela; Radaszkiewicz, Katarzyna Anna; Ovesná, Petra; Bryja, Vítězslav; Souček, Karel

Orthotopic model for the analysis of melanoma circulating tumor cells. Journal Article

In: Scientific reports, vol. 14, no. 1, pp. 7827, 2024, ISSN: 2045-2322, (Place: England).

Abstract | Links | BibTeX | Tags: *Melanoma/pathology, *Neoplastic Cells, *Skin Neoplasms/pathology, Animals, Circulating tumor cells, Circulating/pathology, Flow Cytometry, Humans, In vivo model, Lymphatic Metastasis, Melanoma, Metastasis, Tumorectomy

Hýžďalová, Martina; Procházková, Jiřina; Straková, Nicol; Pěnčíková, Kateřina; Strapáčová, Simona; Slováčková, Jana; Kajabová, Simona; Líbalová, Helena; Topinka, Jan; Kabátková, Markéta; Vondráček, Jan; Mollerup, Steen; Machala, Miroslav

Transcriptional and phenotypical alterations associated with a gradual benzo[a]pyrene-induced transition of human bronchial epithelial cells into mesenchymal-like cells. Journal Article

In: Environmental toxicology and pharmacology, vol. 107, pp. 104424, 2024, ISSN: 1872-7077 1382-6689, (Place: Netherlands).

Abstract | Links | BibTeX | Tags: *Benzo(a)pyrene/toxicity, *Epithelial Cells/metabolism, 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin, Aryl hydrocarbon receptor, Aryl Hydrocarbon/genetics/metabolism, Benzo[a]pyrene, DNA Damage, Epithelial-Mesenchymal Transition, Human bronchial epithelial cells, Humans, Ligands, Receptors

Procházková, Jiřina; Kahounová, Zuzana; Vondráček, Jan; Souček, Karel

Aryl hydrocarbon receptor as a drug target in advanced prostate cancer therapy - obstacles and perspectives. Journal Article

In: Transcription, pp. 1–20, 2024, ISSN: 2154-1272, (Place: United States).

Abstract | Links | BibTeX | Tags: antibody-drug conjugates, Aryl hydrocarbon receptor, castration resistance, Prostate cancer

Chrenková, Eva; Študentová, Hana; Holá, Kateřina; Kahounová, Zuzana; Hendrychová, Romana; Souček, Karel; Bouchal, Jan

Castration-resistant prostate cancer monitoring by cell-free circulating biomarkers. Journal Article

In: Frontiers in oncology, vol. 14, pp. 1394292, 2024, ISSN: 2234-943X, (Place: Switzerland).

Abstract | Links | BibTeX | Tags: biomarker, castration-resistant prostate cancer, liquid biopsy, progression monitoring, therapy response

2023

Holme, Jørn A.; Vondráček, Jan; Machala, Miroslav; Lagadic-Gossmann, Dominique; Vogel, Christoph F. A.; Ferrec, Eric Le; Sparfel, Lydie; Øvrevik, Johan

Lung cancer associated with combustion particles and fine particulate matter (PM(2.5)) - The roles of polycyclic aromatic hydrocarbons (PAHs) and the aryl hydrocarbon receptor (AhR). Journal Article

In: Biochemical pharmacology, vol. 216, pp. 115801, 2023, ISSN: 1873-2968 0006-2952, (Place: England).

Abstract | Links | BibTeX | Tags: *Air Pollutants/toxicity, *Lung Neoplasms/chemically induced/genetics, *Polycyclic Aromatic Hydrocarbons/toxicity, Air pollution, Aryl Hydrocarbon/genetics, Carcinogenesis, Diesel exhaust, Environmental Monitoring, Genotoxicity, Humans, Inflammation, Occupational exposure, Particulate Matter/toxicity, Receptors, Smoking, Tumor metastasis, Tumor microenvironment, Tumor promotion

Vázquez-Gómez, Gerardo; Petráš, Jiří; Dvořák, Zdeněk; Vondráček, Jan

Aryl hydrocarbon receptor (AhR) and pregnane X receptor (PXR) play both distinct and common roles in the regulation of colon homeostasis and intestinal carcinogenesis. Journal Article

In: Biochemical pharmacology, vol. 216, pp. 115797, 2023, ISSN: 1873-2968 0006-2952, (Place: England).

Abstract | Links | BibTeX | Tags: *Receptors, Animals, Aryl hydrocarbon receptor, Aryl Hydrocarbon/genetics/metabolism, Carcinogenesis/genetics/metabolism, Colon cancer, Colon/metabolism, Dietary contaminants, Epithelial barrier, Inflammation, Inflammation/metabolism, Intestine, Mice, Microbial agonists, Pregnane X receptor, Pregnane X Receptor/metabolism, Steroid/metabolism

Sládeková, Lucia; Zgarbová, Eliška; Vrzal, Radim; Vanda, David; Soural, Miroslav; Jakubcová, Klára; Vázquez-Gómez, Gerardo; Vondráček, Jan; Dvořák, Zdeněk

Switching on/off aryl hydrocarbon receptor and pregnane X receptor activities by chemically modified tryptamines. Journal Article

In: Toxicology letters, vol. 387, pp. 63–75, 2023, ISSN: 1879-3169 0378-4274, (Place: Netherlands).

Abstract | Links | BibTeX | Tags: *Receptors, Aryl hydrocarbon receptor, Aryl Hydrocarbon/metabolism, Caco-2 Cells, Humans, Indoles/pharmacology, Microbial indoles, Pregnane X receptor, Pregnane X Receptor/genetics, Steroid/metabolism, Tryptamine, Tryptamines/pharmacology

Kahounová, Zuzana; Pícková, Markéta; Drápela, Stanislav; Bouchal, Jan; Szczyrbová, Eva; Navrátil, Jiří; Souček, Karel

Circulating tumor cell-derived preclinical models: current status and future perspectives. Journal Article

In: Cell death & disease, vol. 14, no. 8, pp. 530, 2023, ISSN: 2041-4889, (Place: England).

Abstract | Links | BibTeX | Tags: *Neoplastic Cells, Cell Culture Techniques, Circulating, Heterografts, Heterologous, Humans, Precision Medicine, Transplantation

Marvanová, Soňa; Pěnčíková, Kateřina; Pálková, Lenka; Ciganek, Miroslav; Petráš, Jiří; Lněničková, Anna; Vondráček, Jan; Machala, Miroslav

Benzo[b]naphtho[d]thiophenes and naphthylbenzo[b]thiophenes: Their aryl hydrocarbon receptor-mediated activities and environmental presence. Journal Article

In: The Science of the total environment, vol. 879, pp. 162924, 2023, ISSN: 1879-1026 0048-9697, (Place: Netherlands).

Abstract | Links | BibTeX | Tags: *Environmental Pollutants, *Heterocyclic Compounds, AhR activity, Airborne particulate matter, Animals, Aryl Hydrocarbon, Freshwater sediments, Gap junctional intercellular communication, Humans, Particulate Matter, Polycyclic aromatic sulfur heterocyclic compounds, Rats, Receptors, Thiophenes/toxicity/metabolism

Kvokačková, Barbora; Fedr, Radek; Kužílková, Daniela; Stuchlý, Jan; Vávrová, Adéla; Navrátil, Jiří; Fabian, Pavel; Ondruššek, Róbert; Ovesná, Petra; Remšík, Ján; Bouchal, Jan; Kalina, Tomáš; Souček, Karel

Single-cell protein profiling defines cell populations associated with triple-negative breast cancer aggressiveness. Journal Article

In: Molecular oncology, vol. 17, no. 6, pp. 1024–1040, 2023, ISSN: 1878-0261 1574-7891, (Place: United States).

Abstract | Links | BibTeX | Tags: *Triple Negative Breast Neoplasms/metabolism, Cell Line, Humans, mass cytometry, phenotypic plasticity, Proteomics, Retrospective Studies, Signal Transduction, single-cell profiles, Stromal Cells/metabolism, triple-negative breast cancer, Tumor, tumor heterogeneity, Tumor microenvironment, unsupervised machine learning algorithm

Fedr, Radek; Kahounová, Zuzana; Remšík, Ján; Reiterová, Michaela; Kalina, Tomáš; Souček, Karel

Variability of fluorescence intensity distribution measured by flow cytometry is influenced by cell size and cell cycle progression. Journal Article

In: Scientific reports, vol. 13, no. 1, pp. 4889, 2023, ISSN: 2045-2322, (Place: England).

Abstract | Links | BibTeX | Tags: *G2 Phase, Cell Cycle/physiology, Cell Division, Cell Size, Flow Cytometry/methods

Culig, Zoran; Jolly, Mohit Kumar; Souček, Karel

Editorial: Heterogeneity and plasticity of prostate cancer. Journal Article

In: Frontiers in molecular biosciences, vol. 10, pp. 1228126, 2023, ISSN: 2296-889X, (Place: Switzerland).

Links | BibTeX | Tags: heterogeneity, immunotherapy, oncogenic miRNA, Plasticity, Prostate cancer, therapy resistance, Transcription Factors, tumor-suppressive miRNA

Ondruššek, Róbert; Kvokačková, Barbora; Kryštofová, Karolína; Brychtová, Světlana; Souček, Karel; Bouchal, Jan

Prognostic value and multifaceted roles of tetraspanin CD9 in cancer. Journal Article

In: Frontiers in oncology, vol. 13, pp. 1140738, 2023, ISSN: 2234-943X, (Place: Switzerland).

Abstract | Links | BibTeX | Tags: cancer, CD9, exosomes, Immunohistochemistry, Prognosis

2022

Bernal, Kévin; Touma, Charbel; Erradhouani, Chedi; Boronat-Belda, Talía; Gaillard, Lucas; Kassir, Sara Al; Mentec, Hélène Le; Martin-Chouly, Corinne; Podechard, Normand; Lagadic-Gossmann, Dominique; Langouet, Sophie; Brion, François; Knoll-Gellida, Anja; Babin, Patrick J.; Sovadinova, Iva; Babica, Pavel; Andreau, Karine; Barouki, Robert; Vondracek, Jan; Alonso-Magdalena, Paloma; Blanc, Etienne; Kim, Min Ji; Coumoul, Xavier

Combinatorial pathway disruption is a powerful approach to delineate metabolic impacts of endocrine disruptors. Journal Article

In: FEBS letters, vol. 596, no. 24, pp. 3107–3123, 2022, ISSN: 1873-3468 0014-5793, (Place: England).

Abstract | Links | BibTeX | Tags: *Endocrine Disruptors/toxicity, *Metabolic Syndrome, appetite, bisphenol, dioxin, Humans, Inflammation, insulin resistance, microbiota, Obesity/chemically induced, perfluorinated compounds, Phenols, phthalate, TBT

Kotasová, Hana; Capandová, Michaela; Pelková, Vendula; Dumková, Jana; Koledová, Zuzana; Remšík, Ján; Souček, Karel; Garlíková, Zuzana; Sedláková, Veronika; Rabata, Anas; Vaňhara, Petr; Moráň, Lukáš; Pečinka, Lukáš; Porokh, Volodymyr; Kučírek, Martin; Streit, Libor; Havel, Josef; Hampl, Aleš

Expandable Lung Epithelium Differentiated from Human Embryonic Stem Cells. Journal Article

In: Tissue engineering and regenerative medicine, vol. 19, no. 5, pp. 1033–1050, 2022, ISSN: 2212-5469 1738-2696, (Place: Korea (South)).

Abstract | Links | BibTeX | Tags: *Human Embryonic Stem Cells, Cell Differentiation, Differentiation, Epithelium, Foregut endoderm, hESC, Humans, Lung, Lung/metabolism, Surface-Active Agents/metabolism

Muresan, Ximena M.; Slabáková, Eva; Procházková, Jiřina; Drápela, Stanislav; Fedr, Radek; Pícková, Markéta; Vacek, Ondřej; Víchová, Ráchel; Suchánková, Tereza; Bouchal, Jan; Kürfürstová, Daniela; Král, Milan; Hulínová, Tereza; Sýkora, Radek P.; Študent, Vladimír; Hejret, Václav; Weerden, Wytske M.; Puhr, Martin; Pustka, Václav; Potěšil, David; Zdráhal, Zbyněk; Culig, Zoran; Souček, Karel

Toll-Like Receptor 3 Overexpression Induces Invasion of Prostate Cancer Cells, whereas Its Activation Triggers Apoptosis. Journal Article

In: The American journal of pathology, vol. 192, no. 9, pp. 1321–1335, 2022, ISSN: 1525-2191 0002-9440, (Place: United States).

Abstract | Links | BibTeX | Tags: *Prostatic Neoplasms/pathology, *Toll-Like Receptor 3/genetics/metabolism, Animals, Apoptosis, Cell Line, Humans, Male, Poly I-C/pharmacology, Prostate/pathology, Tumor

Karasová, Martina; Procházková, Jiřina; Tylichová, Zuzana; Fedr, Radek; Ciganek, Miroslav; Machala, Miroslav; Dvořák, Zdeněk; Vyhlídalová, Barbora; Zůvalová, Iveta; Ehrmann, Jiří; Bouchal, Jan; Andrysík, Zdeněk; Vondráček, Jan

Inhibition of Aryl Hydrocarbon Receptor (AhR) Expression Disrupts Cell Proliferation and Alters Energy Metabolism and Fatty Acid Synthesis in Colon Cancer Cells. Journal Article

In: Cancers, vol. 14, no. 17, 2022, ISSN: 2072-6694, (Place: Switzerland).

Abstract | Links | BibTeX | Tags: AhR, Akt pathway, colon cancer cells, fatty acid synthesis, metabolism, proliferation

Smutná, Tereza; Dumková, Jana; Kristeková, Daniela; Laštovičková, Markéta; Jedličková, Adriena; Vrlíková, Lucie; Dočekal, Bohumil; Alexa, Lukáš; Kotasová, Hana; Pelková, Vendula; Večeřa, Zbyněk; Křůmal, Kamil; Petráš, Jiří; Coufalík, Pavel; Všianský, Dalibor; Záchej, Samuel; Pinkas, Dominik; Vondráček, Jan; Hampl, Aleš; Mikuška, Pavel; Buchtová, Marcela

Macrophage-mediated tissue response evoked by subchronic inhalation of lead oxide nanoparticles is associated with the alteration of phospholipases C and cholesterol transporters. Journal Article

In: Particle and fibre toxicology, vol. 19, no. 1, pp. 52, 2022, ISSN: 1743-8977, (Place: England).

Abstract | Links | BibTeX | Tags: *Metal Nanoparticles/chemistry, *Type C Phospholipases, Cholesterol, Cholesterol metabolism, Humans, Inflammation, Inhalation, Lead, Lead oxide nanoparticles, Liver macrophages, Lung macrophages, Macrophages, Oxides

Heindel, Jerrold J.; Howard, Sarah; Agay-Shay, Keren; Arrebola, Juan P.; Audouze, Karine; Babin, Patrick J.; Barouki, Robert; Bansal, Amita; Blanc, Etienne; Cave, Matthew C.; Chatterjee, Saurabh; Chevalier, Nicolas; Choudhury, Mahua; Collier, David; Connolly, Lisa; Coumoul, Xavier; Garruti, Gabriella; Gilbertson, Michael; Hoepner, Lori A.; Holloway, Alison C.; 3rd Howell, George; Kassotis, Christopher D.; Kay, Mathew K.; Kim, Min Ji; Lagadic-Gossmann, Dominique; Langouet, Sophie; Legrand, Antoine; Li, Zhuorui; Mentec, Helene Le; Lind, Lars; Lind, P. Monica; Lustig, Robert H.; Martin-Chouly, Corinne; Kos, Vesna Munic; Podechard, Normand; Roepke, Troy A.; Sargis, Robert M.; Starling, Anne; Tomlinson, Craig R.; Touma, Charbel; Vondracek, Jan; Saal, Frederick Vom; Blumberg, Bruce

Corrigendum to "Obesity II: Establishing causal links between chemical exposures and obesity" [Biochem. Pharmacol. 199 (2022) 115015]. Journal Article

In: Biochemical pharmacology, vol. 202, pp. 115144, 2022, ISSN: 1873-2968 0006-2952, (Place: England).

Links | BibTeX | Tags:

Lenárt, Sára; Lenárt, Peter; Knopfová, Lucia; Kotasová, Hana; Pelková, Vendula; Sedláková, Veronika; Vacek, Ondřej; Pokludová, Jana; Čan, Vladimír; Šmarda, Jan; Souček, Karel; Hampl, Aleš; Beneš, Petr

TACSTD2 upregulation is an early reaction to lung infection. Journal Article

In: Scientific reports, vol. 12, no. 1, pp. 9583, 2022, ISSN: 2045-2322, (Place: England).

Abstract | Links | BibTeX | Tags: *Antigens, *Cell Adhesion Molecules/metabolism, Animals, Epithelial Cells/metabolism, Lung/metabolism, Neoplasm/metabolism, Up-Regulation

Heindel, Jerrold J.; Howard, Sarah; Agay-Shay, Keren; Arrebola, Juan P.; Audouze, Karine; Babin, Patrick J.; Barouki, Robert; Bansal, Amita; Blanc, Etienne; Cave, Matthew C.; Chatterjee, Saurabh; Chevalier, Nicolas; Choudhury, Mahua; Collier, David; Connolly, Lisa; Coumoul, Xavier; Garruti, Gabriella; Gilbertson, Michael; Hoepner, Lori A.; Holloway, Alison C.; 3rd Howell, George; Kassotis, Christopher D.; Kay, Mathew K.; Kim, Min Ji; Lagadic-Gossmann, Dominique; Langouet, Sophie; Legrand, Antoine; Li, Zhuorui; Mentec, Helene Le; Lind, Lars; Lind, P. Monica; Lustig, Robert H.; Martin-Chouly, Corinne; Kos, Vesna Munic; Podechard, Normand; Roepke, Troy A.; Sargis, Robert M.; Starling, Anne; Tomlinson, Craig R.; Touma, Charbel; Vondracek, Jan; Saal, Frederick Vom; Blumberg, Bruce

Obesity II: Establishing causal links between chemical exposures and obesity. Journal Article

In: Biochemical pharmacology, vol. 199, pp. 115015, 2022, ISSN: 1873-2968 0006-2952, (Place: England).

Abstract | Links | BibTeX | Tags: *Endocrine Disruptors/toxicity, Adipocyte differentiation, Adipogenesis, Adipose Tissue, Child, Endocrine disruptor, Environmental Exposure/adverse effects, Humans, Obesity, Obesity/etiology, Obesogen, Preschool, Weight Gain

Lustig, Robert H.; Collier, David; Kassotis, Christopher; Roepke, Troy A.; Kim, Min Ji; Blanc, Etienne; Barouki, Robert; Bansal, Amita; Cave, Matthew C.; Chatterjee, Saurabh; Choudhury, Mahua; Gilbertson, Michael; Lagadic-Gossmann, Dominique; Howard, Sarah; Lind, Lars; Tomlinson, Craig R.; Vondracek, Jan; Heindel, Jerrold J.

Obesity I: Overview and molecular and biochemical mechanisms. Journal Article

In: Biochemical pharmacology, vol. 199, pp. 115012, 2022, ISSN: 1873-2968 0006-2952, (Place: England).

Abstract | Links | BibTeX | Tags: *Leptin/metabolism, *Obesity/metabolism, Adipocytes/metabolism, Adipose Tissue, Adipose Tissue/metabolism, Energy balance, Energy Metabolism/physiology, Hormone receptors, Humans, Insulin/metabolism, metabolism, Microbiome, Obesity

Říhová, Kamila; Dúcka, Monika; Zambo, Iva Staniczková; Vymětalová, Ladislava; Šrámek, Martin; Trčka, Filip; Verner, Jan; Drápela, Stanislav; Fedr, Radek; Suchánková, Tereza; Pavlatovská, Barbora; Ondroušková, Eva; Kubelková, Irena; Zapletalová, Danica; Tuček, Štěpán; Múdry, Peter; Krákorová, Dagmar Adámková; Knopfová, Lucia; Šmarda, Jan; Souček, Karel; Borsig, Lubor; Beneš, Petr

Transcription factor c-Myb: novel prognostic factor in osteosarcoma. Journal Article

In: Clinical & experimental metastasis, vol. 39, no. 2, pp. 375–390, 2022, ISSN: 1573-7276 0262-0898, (Place: Netherlands).

Abstract | Links | BibTeX | Tags: *Bone Neoplasms/pathology, *Osteosarcoma/pathology, Animals, c-Myb, Cell Line, Cell Movement/genetics, Cell Proliferation, Chemoresistance, Gene Expression Regulation, Humans, Metastasis, Mice, Neoplastic, Osteosarcoma, Prognosis, proliferation, Retrospective Studies, Tumor, Wnt Signaling Pathway

Šimečková, Pavlína; Pěnčíková, Kateřina; Kováč, Ondrej; Slavík, Josef; Pařenicová, Martina; Vondráček, Jan; Machala, Miroslav

In vitro profiling of toxic effects of environmental polycyclic aromatic hydrocarbons on nuclear receptor signaling, disruption of endogenous metabolism and induction of cellular stress. Journal Article

In: The Science of the total environment, vol. 815, pp. 151967, 2022, ISSN: 1879-1026 0048-9697, (Place: Netherlands).

Abstract | Links | BibTeX | Tags: *Polycyclic Aromatic Hydrocarbons/toxicity, Aryl Hydrocarbon/genetics/metabolism, Benzo(a)pyrene, Cellular stress response, Cytoplasmic and Nuclear/genetics, Energy Metabolism, Humans, Nuclear receptors, Polycyclic aromatic hydrocarbons, Receptors, Signal Transduction, Sphingolipids, Xenobiotics

Vázquez-Gómez, Gerardo; Karasová, Martina; Tylichová, Zuzana; Kabátková, Markéta; Hampl, Aleš; Matthews, Jason; Neča, Jiří; Ciganek, Miroslav; Machala, Miroslav; Vondráček, Jan

Aryl Hydrocarbon Receptor (AhR) Limits the Inflammatory Responses in Human Lung Adenocarcinoma A549 Cells via Interference with NF-κB Signaling. Journal Article

In: Cells, vol. 11, no. 4, 2022, ISSN: 2073-4409, (Place: Switzerland).

Abstract | Links | BibTeX | Tags: *Environmental Pollutants/toxicity, *Inflammation/pathology, *NF-kappa B/metabolism, *Receptors, A549 Cells, AhR, alveolar epithelial type II cells, Aryl Hydrocarbon/metabolism, cytokines, Humans, Inflammation, NF-κB, prostaglandins

Krkoška, Martin; Nekvindová, Jana; Nevědělová, Kateřina; Zubáňová, Veronika; Radová, Lenka; Vondráček, Jan; Herůdková, Jarmila; Slabý, Ondřej; Kiss, Igor; Bohovicová, Lucia; Fabian, Pavel; Tylichová, Zuzana; Kala, Zdeněk; Kysela, Petr; Ostřížková, Lenka; Palička, Vladimír; Vaculová, Alena Hyršlová

Role of miR-653 and miR-29c in downregulation of CYP1A2 expression in hepatocellular carcinoma. Journal Article

In: Pharmacological reports : PR, vol. 74, no. 1, pp. 148–158, 2022, ISSN: 2299-5684 1734-1140, (Place: Switzerland).

Abstract | Links | BibTeX | Tags: *Carcinoma, *Liver Neoplasms/genetics/metabolism, AhR, Biotransformation, Cell Line, CYP1A2, Cytochrome P-450 CYP1A2/*metabolism, Down-Regulation, Gene Expression Regulation, Hepatocellular carcinoma, Hepatocellular/genetics/metabolism, Hepatocytes/metabolism, Humans, MicroRNA, MicroRNAs/*metabolism, Neoplastic, Tumor, Xenobiotics/metabolism

Drápela, Stanislav; Fedr, Radek; Vacek, Ondřej; Remšík, Ján; Souček, Karel

High-Throughput, Parallel Flow Cytometry Screening of Hundreds of Cell Surface Antigens Using Fluorescent Barcoding. Journal Article

In: Methods in molecular biology (Clifton, N.J.), vol. 2543, pp. 99–111, 2022, ISSN: 1940-6029 1064-3745, (Place: United States).

Abstract | Links | BibTeX | Tags: *Antigens, *Research, Biomarkers/analysis, Cell surface phenotyping, Flow Cytometry, Fluorescent cell barcoding, Fluorescent Dyes, High-throughput screening, Multicolor flow cytometry, Surface

2021

Slabáková, Eva; Kahounová, Zuzana; Procházková, Jiřina; Souček, Karel

Regulation of Neuroendocrine-like Differentiation in Prostate Cancer by Non-Coding RNAs. Journal Article

In: Non-coding RNA, vol. 7, no. 4, 2021, ISSN: 2311-553X, (Place: Switzerland).

Abstract | Links | BibTeX | Tags: exosomes, extracellular vesicles, liquid biomarkers, lncRNA, MicroRNA, neuroendocrine differentiation/transdifferentiation, patients’ dataset, Prostate cancer

Radaszkiewicz, Tomasz; Nosková, Michaela; Gömöryová, Kristína; Blanářová, Olga Vondálová; Radaszkiewicz, Katarzyna Anna; Picková, Markéta; Víchová, Ráchel; Gybeľ, Tomáš; Kaiser, Karol; Demková, Lucia; Kučerová, Lucia; Bárta, Tomáš; Potěšil, David; Zdráhal, Zbyněk; Souček, Karel; Bryja, Vítězslav

RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy. Journal Article

In: eLife, vol. 10, 2021, ISSN: 2050-084X, (Place: England).

Abstract | Links | BibTeX | Tags: *Melanoma/genetics/pathology/prevention & control, *Signal Transduction, Animals, BRAF V600E, cancer biology, cell biology, human, Inbred NOD, Male, Melanoma, Mice, mouse, Neoplasm Invasiveness/genetics, RNF43, ROR1, Ubiquitin-Protein Ligases/*genetics/metabolism, VANGL1, Wnt-5a Protein/*genetics/metabolism, WNT5A

Krkoška, Martin; Svobodová, Jana; Kabátková, Markéta; Zapletal, Ondřej; Vaculová, Alena Hyršlová; Nekvindová, Jana; Vondráček, Jan

Deregulation of signaling pathways controlling cell survival and proliferation in cancer cells alters induction of cytochrome P450 family 1 enzymes. Journal Article

In: Toxicology, vol. 461, pp. 152897, 2021, ISSN: 1879-3185 0300-483X, (Place: Ireland).

Abstract | Links | BibTeX | Tags: AhR, Cancer cells, Cell Line, Cell Proliferation, Cell Proliferation/*physiology, Cell Survival/physiology, Colonic Neoplasms/genetics/*pathology, CYP1 enzymes, Cytochrome P-450 CYP1A1/biosynthesis/*genetics, E1A-Associated p300 Protein/metabolism, Enzyme Induction/physiology, Gene Expression Regulation, HCT116 Cells, Hippo Signaling Pathway/physiology, Humans, Liver/*pathology, Neoplastic, p300, Signal Transduction/physiology, Tumor, Wnt Signaling Pathway/physiology, β-Catenin signaling

Machala, Miroslav; Slavík, Josef; Kováč, Ondrej; Procházková, Jiřina; Pěnčíková, Kateřina; Pařenicová, Martina; Straková, Nicol; Kotouček, Jan; Kulich, Pavel; Mollerup, Steen; Vondráček, Jan; Hýžďalová, Martina

Changes in Sphingolipid Profile of Benzo[a]pyrene-Transformed Human Bronchial Epithelial Cells Are Reflected in the Altered Composition of Sphingolipids in Their Exosomes. Journal Article

In: International journal of molecular sciences, vol. 22, no. 17, 2021, ISSN: 1422-0067, (Place: Switzerland).

Abstract | Links | BibTeX | Tags: *Cell Transformation, Benzo(a)pyrene/toxicity, Bronchi/cytology, Carcinogens/toxicity, Cell Line, eicosanoids, exosomes, Exosomes/*metabolism, glycosphingolipid, Humans, in vitro cell transformation, Neoplastic, Respiratory Mucosa/drug effects/*metabolism, sphingolipid, Sphingolipids/*metabolism

Hofmanová, Jiřina; Slavík, Josef; Ciganek, Miroslav; Ovesná, Petra; Tylichová, Zuzana; Karasová, Martina; Zapletal, Ondřej; Straková, Nicol; Procházková, Jiřina; Bouchal, Jan; Kolář, Zdeněk; Ehrmann, Jiří; Levková, Monika; Hušková, Zlatka; Skalický, Pavel; Kozubík, Alois; Machala, Miroslav; Vondráček, Jan

Complex Alterations of Fatty Acid Metabolism and Phospholipidome Uncovered in Isolated Colon Cancer Epithelial Cells. Journal Article

In: International journal of molecular sciences, vol. 22, no. 13, 2021, ISSN: 1422-0067, (Place: Switzerland).

Abstract | Links | BibTeX | Tags: *Gene Expression Regulation, *Lipid Metabolism, Adenocarcinoma/enzymology/genetics/*metabolism, Aged, Colonic Neoplasms/enzymology/genetics/*metabolism, colorectal carcinoma, desaturation, EpCAM, Epithelial Cells, Epithelial Cells/enzymology/metabolism, Fatty Acid Desaturases/genetics/metabolism, Fatty Acid Elongases/genetics/metabolism, Fatty Acid Synthases/genetics/metabolism, fatty acid synthesis, Fatty Acids/*metabolism, Female, Humans, lipidomics, Lipogenesis, lysophospholipids, Male, Neoplastic, Phospholipids, Phospholipids/*metabolism, Stearoyl-CoA Desaturase/genetics/metabolism

Kvokačková, Barbora; Remšík, Ján; Jolly, Mohit Kumar; Souček, Karel

Phenotypic Heterogeneity of Triple-Negative Breast Cancer Mediated by Epithelial-Mesenchymal Plasticity. Journal Article

In: Cancers, vol. 13, no. 9, 2021, ISSN: 2072-6694, (Place: Switzerland).

Abstract | Links | BibTeX | Tags: epithelial–mesenchymal transition, mesenchymal–epithelial transition, Metastasis, Plasticity, triple-negative breast cancer

Němec, Václav; Maier, Lukáš; Berger, Benedict-Tilman; Chaikuad, Apirat; Drápela, Stanislav; Souček, Karel; Knapp, Stefan; Paruch, Kamil

Highly selective inhibitors of protein kinases CLK and HIPK with the furo[3,2-b]pyridine core. Journal Article

In: European journal of medicinal chemistry, vol. 215, pp. 113299, 2021, ISSN: 1768-3254 0223-5234, (Place: France).

Abstract | Links | BibTeX | Tags: 2-b]pyridine, Animals, Carrier Proteins/*antagonists & inhibitors/metabolism, CLK, Crystallography, Furans/chemical synthesis/metabolism/*pharmacology, Furo[3, HIPK, Humans, Inhibitor, Kinase, MCF-7 Cells, Mice, Molecular Structure, MU1210, MU135, MU1787, Protein Binding, Protein Kinase Inhibitors/chemical synthesis/metabolism/*pharmacology, Protein Serine-Threonine Kinases/*antagonists & inhibitors/metabolism, Pyridines/chemical synthesis/metabolism/*pharmacology, Structure-Activity Relationship, X-Ray

Mickova, Alena; Kharaishvili, Gvantsa; Kurfurstova, Daniela; Gachechiladze, Mariam; Kral, Milan; Vacek, Ondrej; Pokryvkova, Barbora; Mistrik, Martin; Soucek, Karel; Bouchal, Jan

Skp2 and Slug Are Coexpressed in Aggressive Prostate Cancer and Inhibited by Neddylation Blockade. Journal Article

In: International journal of molecular sciences, vol. 22, no. 6, 2021, ISSN: 1422-0067, (Place: Switzerland).

Abstract | Links | BibTeX | Tags: *Protein Processing, Androgen/genetics/metabolism, Antigens, Antineoplastic Agents/pharmacology, Cadherins/genetics/metabolism, CD/genetics/metabolism, Cell Line, Cell Survival/drug effects, Cyclin-Dependent Kinase Inhibitor p27/genetics/metabolism, Cyclopentanes/pharmacology, Docetaxel/pharmacology, Epithelial-Mesenchymal Transition/genetics, Gene Expression Regulation, Humans, Immunohistochemistry, Lymphatic Metastasis, Male, multiplex, NEDD8 Protein/*genetics/metabolism, neddylation, Neoplasm Grading, Neoplastic, PC-3 Cells, Post-Translational, Prostate cancer, Prostate/metabolism/pathology, Prostatic Neoplasms/*genetics/metabolism/pathology, Pyrimidines/pharmacology, Receptors, RNA, S-Phase Kinase-Associated Proteins/antagonists & inhibitors/*genetics/metabolism, Skp2 (S-phase kinase-associated protein 2), Slug, Small Interfering/genetics/metabolism, Snail Family Transcription Factors/*genetics/metabolism, Tumor

Hýžďalová, Martina; Procházková, Jiřina; Strapáčová, Simona; Svržková, Lucie; Vacek, Ondřej; Fedr, Radek; Andrysík, Zdeněk; Hrubá, Eva; Líbalová, Helena; Kléma, Jiří; Topinka, Jan; Mašek, Josef; Souček, Karel; Vondráček, Jan; Machala, Miroslav

A prolonged exposure of human lung carcinoma epithelial cells to benzo[a]pyrene induces p21-dependent epithelial-to-mesenchymal transition (EMT)-like phenotype. Journal Article

In: Chemosphere, vol. 263, pp. 128126, 2021, ISSN: 1879-1298 0045-6535, (Place: England).

Abstract | Links | BibTeX | Tags: *Carcinoma, *Lung Neoplasms/genetics, Aryl Hydrocarbon/genetics, BaP, Benzo(a)pyrene/toxicity, Cell Proliferation, EMT, Epithelial Cells, Humans, Lung, Lung carcinoma, Phenotype, Receptors, TCDD, Tumor progression

Vondráček, Jan; Machala, Miroslav

The Role of Metabolism in Toxicity of Polycyclic Aromatic Hydrocarbons and their Non-genotoxic Modes of Action. Journal Article

In: Current drug metabolism, vol. 22, no. 8, pp. 584–595, 2021, ISSN: 1875-5453 1389-2002, (Place: Netherlands).

Abstract | Links | BibTeX | Tags: Activation, AhR, Animals, Benzo[a]pyrene, Cell Proliferation, Cell Survival, cell-to-cell communication, DNA Damage, Environmental Pollutants/*pharmacokinetics/*toxicity, Humans, Metabolic, Mutagens/*pharmacokinetics/*toxicity, oxidative stress, PAH metabolism., Polycyclic Aromatic Hydrocarbons/*pharmacokinetics/*toxicity

2020

Lenárt, Sára; Lenárt, Peter; Šmarda, Jan; Remšík, Ján; Souček, Karel; Beneš, Petr

Trop2: Jack of All Trades, Master of None. Journal Article

In: Cancers, vol. 12, no. 11, 2020, ISSN: 2072-6694, (Place: Switzerland).

Abstract | Links | BibTeX | Tags: cancer, epithelial-to-mesenchymal transition, metastases, proliferation, TACSTD2, therapy, Trop2

Muresan, Ximena Maria; Bouchal, Jan; Culig, Zoran; Souček, Karel

Toll-Like Receptor 3 in Solid Cancer and Therapy Resistance. Journal Article

In: Cancers, vol. 12, no. 11, 2020, ISSN: 2072-6694, (Place: Switzerland).

Abstract | Links | BibTeX | Tags: cytokines, dsRNA, Metastasis, therapy resistance, toll-like receptor 3

Vondráček, Jan; Pěnčíková, Kateřina; Ciganek, Miroslav; Pivnička, Jakub; Karasová, Martina; Hýžďalová, Martina; Strapáčová, Simona; Pálková, Lenka; Neča, Jiří; Matthews, Jason; Lom, Michal Vojtíšek; Topinka, Jan; Milcová, Alena; Machala, Miroslav

Environmental six-ring polycyclic aromatic hydrocarbons are potent inducers of the AhR-dependent signaling in human cells. Journal Article

In: Environmental pollution (Barking, Essex : 1987), vol. 266, no. Pt 2, pp. 115125, 2020, ISSN: 1873-6424 0269-7491, (Place: England).

Abstract | Links | BibTeX | Tags: *Polycyclic Aromatic Hydrocarbons, *Receptors, AhR, Anti-estrogenicity, Aryl Hydrocarbon, Carcinogenic PAHs, Genotoxicity, Humans, Lung cell toxicity, Particulate Matter, Signal Transduction, Vehicle Emissions

Drápela, Stanislav; Khirsariya, Prashant; Weerden, Wytske M.; Fedr, Radek; Suchánková, Tereza; Búzová, Diana; Červený, Jan; Hampl, Aleš; Puhr, Martin; Watson, William R.; Culig, Zoran; Krejčí, Lumír; Paruch, Kamil; Souček, Karel

The CHK1 inhibitor MU380 significantly increases the sensitivity of human docetaxel-resistant prostate cancer cells to gemcitabine through the induction of mitotic catastrophe. Journal Article

In: Molecular oncology, vol. 14, no. 10, pp. 2487–2503, 2020, ISSN: 1878-0261 1574-7891, (Place: United States).

Abstract | Links | BibTeX | Tags: *Mitosis/drug effects, Animals, castration-resistant prostate cancer, Cell Death/drug effects, Cell Line, Cell Proliferation/drug effects, Checkpoint Kinase 1, Checkpoint Kinase 1/*antagonists & inhibitors/metabolism, Deoxycytidine/*analogs & derivatives/pharmacology, Docetaxel resistance, Docetaxel/*pharmacology, Drug resistance, gemcitabine, Humans, Male, Mice, mitotic catastrophe, MU380, Neoplasm/*drug effects, Piperidines/chemistry/*pharmacology, Prostatic Neoplasms/*pathology, Pyrazoles/chemistry/*pharmacology, Pyrimidines/chemistry/*pharmacology, S Phase/drug effects, SCID, Tumor, Xenograft Model Antitumor Assays

Procházková, Jiřina; Slavík, Josef; Bouchal, Jan; Levková, Monika; Hušková, Zlata; Ehrmann, Jiří; Ovesná, Petra; Kolář, Zdeněk; Skalický, Pavel; Straková, Nicol; Zapletal, Ondřej; Kozubík, Alois; Hofmanová, Jiřina; Vondráček, Jan; Machala, Miroslav

Specific alterations of sphingolipid metabolism identified in EpCAM-positive cells isolated from human colon tumors. Journal Article

In: Biochimica et biophysica acta. Molecular and cell biology of lipids, vol. 1865, no. 9, pp. 158742, 2020, ISSN: 1879-2618 1388-1981, (Place: Netherlands).

Links | BibTeX | Tags: 80 and over, Adult, Aged, B4GALTs, Colon adenocarcinoma, Colorectal Neoplasms/*metabolism, EPCAM-positive cells, Epithelial Cell Adhesion Molecule/*metabolism, Female, Galactosyltransferases/genetics, Humans, Lactosylceramide, Male, Middle Aged, Sphingolipid metabolism, Sphingolipids/*metabolism

Remšík, Ján; Pícková, Markéta; Vacek, Ondřej; Fedr, Radek; Binó, Lucia; Hampl, Aleš; Souček, Karel

TGF-β regulates Sca-1 expression and plasticity of pre-neoplastic mammary epithelial stem cells. Journal Article

In: Scientific reports, vol. 10, no. 1, pp. 11396, 2020, ISSN: 2045-2322, (Place: England).

Abstract | Links | BibTeX | Tags: Animal/pathology, Animals, Ataxin-1/*metabolism, Breast Neoplasms/genetics/*pathology, Cell Line, Cell Plasticity/genetics, Epithelial Cells/pathology, Epithelial-Mesenchymal Transition/genetics, ErbB-2/genetics, Experimental/genetics/*pathology, Female, Gene Expression Regulation, Humans, Mammary Glands, Mammary Neoplasms, Mice, Neoplastic, Neoplastic Stem Cells/*pathology, Receptor, Recombinant Proteins/genetics/metabolism, Signal Transduction/genetics, Transforming Growth Factor beta/genetics/*metabolism, Tumor/transplantation

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