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2020

Vyhlídalová, Barbora; Krasulová, Kristýna; Pečinková, Petra; Marcalíková, Adéla; Vrzal, Radim; Zemánková, Lenka; Vančo, Jan; Trávníček, Zdeněk; Vondráček, Jan; Karasová, Martina; Mani, Sridhar; Dvořák, Zdeněk

Gut Microbial Catabolites of Tryptophan Are Ligands and Agonists of the Aryl Hydrocarbon Receptor: A Detailed Characterization. Journal Article

In: International journal of molecular sciences, vol. 21, no. 7, 2020, ISSN: 1422-0067, (Place: Switzerland).

Abstract | Links | BibTeX | Tags: *Gastrointestinal Microbiome/drug effects, Animals, Aryl hydrocarbon receptor, Aryl Hydrocarbon/*agonists/*metabolism, Basic Helix-Loop-Helix Transcription Factors/*agonists/*metabolism, Cell Line, Cytochrome P-450 CYP1A1/genetics, Gene Expression, Genes, Genetic, Humans, Indoles, Ligands, Metabolic Networks and Pathways, Mice, Microbiome, Promoter Regions, Protein Binding, Protein Multimerization, Receptors, Reporter, tryptophan, Tryptophan/*metabolism, Tumor

2017

Slabáková, Eva; Culig, Zoran; Remšík, Ján; Souček, Karel

Alternative mechanisms of miR-34a regulation in cancer. Journal Article

In: Cell death & disease, vol. 8, no. 10, pp. e3100, 2017, ISSN: 2041-4889, (Place: England).

Abstract | Links | BibTeX | Tags: *Genes, Animals, Epigenesis, Epithelial-Mesenchymal Transition/genetics, Gene Expression Regulation, Genetic/genetics, Humans, MicroRNAs/*genetics, Neoplasms/*genetics/*pathology, Neoplastic/genetics, Promoter Regions, Tumor Suppressor, Tumor Suppressor Protein p53/*genetics

2013

Procházková, Jiřina; Kabátková, Markéta; Šmerdová, Lenka; Pacherník, Jiří; Sykorová, Dominika; Kohoutek, Jiří; Šimečková, Pavlína; Hrubá, Eva; Kozubík, Alois; Machala, Miroslav; Vondráček, Jan

Aryl hydrocarbon receptor negatively regulates expression of the plakoglobin gene (jup). Journal Article

In: Toxicological sciences : an official journal of the Society of Toxicology, vol. 134, no. 2, pp. 258–270, 2013, ISSN: 1096-0929, (Place: United States).

Abstract | Links | BibTeX | Tags: Animals, Aryl hydrocarbon receptor, Aryl Hydrocarbon/*physiology, Base Sequence, cardiomyocytes., Cell Adhesion, Cell Line, Cell Proliferation, Cloning, desmosomes, dioxin, DNA Primers, Down-Regulation, gamma Catenin/*genetics, Gene Expression Regulation/*physiology, Genetic, Inbred F344, liver progenitor cells, Molecular, plakoglobin, Polychlorinated Dibenzodioxins/pharmacology, Promoter Regions, Rats, Real-Time Polymerase Chain Reaction, Receptors

2009

Takacova, Martina; Holotnakova, Tereza; Vondracek, Jan; Machala, Miroslav; Pencikova, Katerina; Gradin, Katarina; Poellinger, Lorenz; Pastorek, Jaromir; Pastorekova, Silvia; Kopacek, Juraj

Role of aryl hydrocarbon receptor in modulation of the expression of the hypoxia marker carbonic anhydrase IX. Journal Article

In: The Biochemical journal, vol. 419, no. 2, pp. 419–425, 2009, ISSN: 1470-8728 0264-6021, (Place: England).

Abstract | Links | BibTeX | Tags: alpha Subunit, Animals, Antigens, Aryl Hydrocarbon/genetics/metabolism/*physiology, Binding Sites, Blotting, Carbonic Anhydrase IX, Carbonic Anhydrases/genetics/*metabolism, Cell Hypoxia/genetics/*physiology, Cell Line, Chromatin Immunoprecipitation, Genetic/genetics, Humans, Hypoxia-Inducible Factor 1, Mice, Neoplasm/genetics, Polychlorinated Dibenzodioxins/pharmacology, Polymerase Chain Reaction, Promoter Regions, Protein Binding/drug effects, Receptors, Reverse Transcriptase Polymerase Chain Reaction, Signal Transduction/drug effects, Tumor, Western