2022
Bernal, Kévin; Touma, Charbel; Erradhouani, Chedi; Boronat-Belda, Talía; Gaillard, Lucas; Kassir, Sara Al; Mentec, Hélène Le; Martin-Chouly, Corinne; Podechard, Normand; Lagadic-Gossmann, Dominique; Langouet, Sophie; Brion, François; Knoll-Gellida, Anja; Babin, Patrick J.; Sovadinova, Iva; Babica, Pavel; Andreau, Karine; Barouki, Robert; Vondracek, Jan; Alonso-Magdalena, Paloma; Blanc, Etienne; Kim, Min Ji; Coumoul, Xavier
Combinatorial pathway disruption is a powerful approach to delineate metabolic impacts of endocrine disruptors. Journal Article
In: FEBS letters, vol. 596, no. 24, pp. 3107–3123, 2022, ISSN: 1873-3468 0014-5793, (Place: England).
Abstract | Links | BibTeX | Tags: *Endocrine Disruptors/toxicity, *Metabolic Syndrome, appetite, bisphenol, dioxin, Humans, Inflammation, insulin resistance, microbiota, Obesity/chemically induced, perfluorinated compounds, Phenols, phthalate, TBT
@article{bernal_combinatorial_2022,
title = {Combinatorial pathway disruption is a powerful approach to delineate metabolic impacts of endocrine disruptors.},
author = {Kévin Bernal and Charbel Touma and Chedi Erradhouani and Talía Boronat-Belda and Lucas Gaillard and Sara Al Kassir and Hélène Le Mentec and Corinne Martin-Chouly and Normand Podechard and Dominique Lagadic-Gossmann and Sophie Langouet and François Brion and Anja Knoll-Gellida and Patrick J. Babin and Iva Sovadinova and Pavel Babica and Karine Andreau and Robert Barouki and Jan Vondracek and Paloma Alonso-Magdalena and Etienne Blanc and Min Ji Kim and Xavier Coumoul},
doi = {10.1002/1873-3468.14465},
issn = {1873-3468 0014-5793},
year = {2022},
date = {2022-12-01},
journal = {FEBS letters},
volume = {596},
number = {24},
pages = {3107–3123},
abstract = {The prevalence of metabolic diseases, such as obesity, diabetes, metabolic syndrome and chronic liver diseases among others, has been rising for several years. Epidemiology and mechanistic (in vivo, in vitro and in silico) toxicology have recently provided compelling evidence implicating the chemical environment in the pathogenesis of these diseases. In this review, we will describe the biological processes that contribute to the development of metabolic diseases targeted by metabolic disruptors, and will propose an integrated pathophysiological vision of their effects on several organs. With regard to these pathomechanisms, we will discuss the needs, and the stakes of evolving the testing and assessment of endocrine disruptors to improve the prevention and management of metabolic diseases that have become a global epidemic since the end of last century.},
note = {Place: England},
keywords = {*Endocrine Disruptors/toxicity, *Metabolic Syndrome, appetite, bisphenol, dioxin, Humans, Inflammation, insulin resistance, microbiota, Obesity/chemically induced, perfluorinated compounds, Phenols, phthalate, TBT},
pubstate = {published},
tppubtype = {article}
}