Latest Publications

@article{prochazkova_specific_2020,

title = {Specific alterations of sphingolipid metabolism identified in EpCAM-positive cells isolated from human colon tumors.},

author = {Jiřina Procházková and Josef Slavík and Jan Bouchal and Monika Levková and Zlata Hušková and Jiří Ehrmann and Petra Ovesná and Zdeněk Kolář and Pavel Skalický and Nicol Straková and Ondřej Zapletal and Alois Kozubík and Jiřina Hofmanová and Jan Vondráček and Miroslav Machala},

doi = {10.1016/j.bbalip.2020.158742},

issn = {1879-2618 1388-1981},

year  = {2020},

date = {2020-09-01},

journal = {Biochimica et biophysica acta. Molecular and cell biology of lipids},

volume = {1865},

number = {9},

pages = {158742},

note = {Place: Netherlands},

keywords = {80 and over, Adult, Aged, B4GALTs, Colon adenocarcinoma, Colorectal Neoplasms/*metabolism, EPCAM-positive cells, Epithelial Cell Adhesion Molecule/*metabolism, Female, Galactosyltransferases/genetics, Humans, Lactosylceramide, Male, Middle Aged, Sphingolipid metabolism, Sphingolipids/*metabolism},

pubstate = {published},

tppubtype = {article}

}

@article{machala_colon_2019,

title = {Colon Cancer and Perturbations of the Sphingolipid Metabolism.},

author = {Miroslav Machala and Jiřina Procházková and Jiřina Hofmanová and Lucie Králiková and Josef Slavík and Zuzana Tylichová and Petra Ovesná and Alois Kozubík and Jan Vondráček},

doi = {10.3390/ijms20236051},

issn = {1422-0067},

year  = {2019},

date = {2019-11-01},

journal = {International journal of molecular sciences},

volume = {20},

number = {23},

abstract = {The development and progression of colorectal cancer (CRC), a major cause of cancer-related death in the western world, is accompanied with alterations of sphingolipid (SL) composition in colon tumors. A number of enzymes involved in the SL metabolism have been found to be deregulated in human colon tumors, in experimental rodent studies, and in human colon cancer cells in vitro. Therefore, the enzymatic pathways that modulate SL levels have received a significant attention, due to their possible contribution to CRC development, or as potential therapeutic targets. Many of these enzymes are associated with an increased sphingosine-1-phosphate/ceramide ratio, which is in turn linked with increased colon cancer cell survival, proliferation and cancer progression. Nevertheless, more attention should also be paid to the more complex SLs, including specific glycosphingolipids, such as lactosylceramides, which can be also deregulated during CRC development. In this review, we focus on the potential roles of individual SLs/SL metabolism enzymes in colon cancer, as well as on the pros and cons of employing the current in vitro models of colon cancer cells for lipidomic studies investigating the SL metabolism in CRC.},

note = {Place: Switzerland},

keywords = {*Gene Expression Regulation, Acid Ceramidase/genetics/metabolism, Alkaline Ceramidase/genetics/metabolism, Animal, Animals, Ceramides/metabolism, colon cancer (CRC) sphingolipidomics, colon cancer cells, Colonic Neoplasms/*enzymology/genetics/pathology, colorectal cancer, Cultured, Disease Models, glycosphingolipid, Humans, Lactosylceramide, Lactosylceramides/*metabolism, Lipid Metabolism/*genetics, Lysophospholipids/metabolism, Neoplastic, Neutral Ceramidase/genetics/metabolism, Phosphotransferases (Alcohol Group Acceptor)/genetics/metabolism, Proto-Oncogene Proteins c-akt/genetics/metabolism, sphingolipid, Sphingolipids/*metabolism, Sphingosine N-Acyltransferase/genetics/metabolism, sphingosine-1-phosphate, Sphingosine/analogs & derivatives/metabolism, Tumor Cells},

pubstate = {published},

tppubtype = {article}

}