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2020

Vyhlídalová, Barbora; Krasulová, Kristýna; Pečinková, Petra; Marcalíková, Adéla; Vrzal, Radim; Zemánková, Lenka; Vančo, Jan; Trávníček, Zdeněk; Vondráček, Jan; Karasová, Martina; Mani, Sridhar; Dvořák, Zdeněk

Gut Microbial Catabolites of Tryptophan Are Ligands and Agonists of the Aryl Hydrocarbon Receptor: A Detailed Characterization. Journal Article

In: International journal of molecular sciences, vol. 21, no. 7, 2020, ISSN: 1422-0067, (Place: Switzerland).

Abstract | Links | BibTeX | Tags: *Gastrointestinal Microbiome/drug effects, Animals, Aryl hydrocarbon receptor, Aryl Hydrocarbon/*agonists/*metabolism, Basic Helix-Loop-Helix Transcription Factors/*agonists/*metabolism, Cell Line, Cytochrome P-450 CYP1A1/genetics, Gene Expression, Genes, Genetic, Humans, Indoles, Ligands, Metabolic Networks and Pathways, Mice, Microbiome, Promoter Regions, Protein Binding, Protein Multimerization, Receptors, Reporter, tryptophan, Tryptophan/*metabolism, Tumor

2008

Topinka, Jan; Marvanová, Sona; Vondrácek, Jan; Sevastyanova, Oksana; Nováková, Zuzana; Krcmár, Pavel; Pencíková, Katerina; Machala, Miroslav

DNA adducts formation and induction of apoptosis in rat liver epithelial 'stem-like' cells exposed to carcinogenic polycyclic aromatic hydrocarbons. Journal Article

In: Mutation research, vol. 638, no. 1-2, pp. 122–132, 2008, ISSN: 0027-5107, (Place: Netherlands).

Abstract | Links | BibTeX | Tags: *Apoptosis, Animals, Aryl Hydrocarbon Hydroxylases/genetics, Cells, Cultured, Cytochrome P-450 CYP1A1/genetics, Cytochrome P-450 CYP1B1, DNA Adducts/*metabolism, Inbred F344, Liver/*cytology, Messenger/analysis, Polycyclic Aromatic Hydrocarbons/*pharmacology, Rats, RNA, Stem Cells/*metabolism

2007

Andrysík, Zdenek; Vondrácek, Jan; Machala, Miroslav; Krcmár, Pavel; Svihálková-Sindlerová, Lenka; Kranz, Anne; Weiss, Carsten; Faust, Dagmar; Kozubík, Alois; Dietrich, Cornelia

The aryl hydrocarbon receptor-dependent deregulation of cell cycle control induced by polycyclic aromatic hydrocarbons in rat liver epithelial cells. Journal Article

In: Mutation research, vol. 615, no. 1-2, pp. 87–97, 2007, ISSN: 0027-5107, (Place: Netherlands).

Abstract | Links | BibTeX | Tags: Animals, Apoptosis/drug effects, Aryl Hydrocarbon/antagonists & inhibitors/genetics/*metabolism, Base Sequence, Benz(a)Anthracenes/toxicity, Benzo(a)pyrene/toxicity, Cell Cycle Proteins/metabolism, Cell Cycle/*drug effects/*physiology, Cell Line, Cell Proliferation/drug effects, Cyclin A/metabolism, Cyclin-Dependent Kinase 2/metabolism, Cytochrome P-450 CYP1A1/genetics, Epithelial Cells/cytology/drug effects/metabolism, Fluorenes/toxicity, Gene Expression/drug effects, Hepatocytes/cytology/*drug effects/*metabolism, Messenger/genetics/metabolism, Multiprotein Complexes, Mutagens/toxicity, Mutation, Polycyclic Aromatic Hydrocarbons/*toxicity, Rats, Receptors, RNA, Small Interfering/genetics

2006

Vondrácek, Jan; Svihálková-Sindlerová, Lenka; Pencíková, Katerina; Krcmár, Pavel; Andrysík, Zdenek; Chramostová, Katerina; Marvanová, Sona; Valovicová, Zuzana; Kozubík, Alois; Gábelová, Alena; Machala, Miroslav

7H-Dibenzo[c,g]carbazole and 5,9-dimethyldibenzo[c,g]carbazole exert multiple toxic events contributing to tumor promotion in rat liver epithelial 'stem-like' cells. Journal Article

In: Mutation research, vol. 596, no. 1-2, pp. 43–56, 2006, ISSN: 0027-5107, (Place: Netherlands).

Abstract | Links | BibTeX | Tags: Animals, Aryl Hydrocarbon Hydroxylases/genetics, Base Sequence, Carbazoles/*toxicity, Carcinogens/*toxicity, Cell Death/drug effects, Cytochrome P-450 CYP1A1/genetics, Cytochrome P-450 CYP1A2/genetics, Cytochrome P-450 CYP1B1, DNA Primers, Epithelial Cells/drug effects/*pathology, Inbred F344, Liver/*cytology/drug effects, Methylation, Molecular Structure, Mutagens, Rats, Reverse Transcriptase Polymerase Chain Reaction