2019
Šimek, Matěj; Hermannová, Martina; Šmejkalová, Daniela; Foglová, Tereza; Souček, Karel; Binó, Lucia; Velebný, Vladimír
LC-MS/MS study of in vivo fate of hyaluronan polymeric micelles carrying doxorubicin. Journal Article
In: Carbohydrate polymers, vol. 209, pp. 181–189, 2019, ISSN: 1879-1344 0144-8617, (Place: England).
Abstract | Links | BibTeX | Tags: *Micelles, Animals, Biodistribution, Chromatography, Doxorubicin, Doxorubicin/*chemistry/pharmacokinetics, Drug Carriers/*chemistry, Drug Liberation, Female, Hyaluronan, Hyaluronic Acid/*chemistry, Liquid, Mice, Molecular Weight, Pharmacokinetics, Polymeric micelles, Tandem Mass Spectrometry, Tissue Distribution
@article{simek_lc-msms_2019,
title = {LC-MS/MS study of in vivo fate of hyaluronan polymeric micelles carrying doxorubicin.},
author = {Matěj Šimek and Martina Hermannová and Daniela Šmejkalová and Tereza Foglová and Karel Souček and Lucia Binó and Vladimír Velebný},
doi = {10.1016/j.carbpol.2018.12.104},
issn = {1879-1344 0144-8617},
year = {2019},
date = {2019-04-01},
journal = {Carbohydrate polymers},
volume = {209},
pages = {181–189},
abstract = {A better understanding of in vivo behavior of nanocarriers is necessary for further improvement in their development. Here we present a novel approach, where both the matrix and the drug can be analyzed by LCMS/MS after one sample handling. The developed method was applied for the comparison of pharmacokinetic profile of free and encapsulated doxorubicin (DOX) in oleyl hyaluronan (HA-C18:1) polymeric micelles. The results indicated that nanocarriers were rapidly dissociated upon in vivo administration. Despite this fact, the administration of encapsulated DOX led to its longer circulation time and enhanced tumor targeting. This effect was not observed injecting blank HA-C18:1 micelles followed by unencapsulated DOX. Biodistribution studies and molecular weight estimation of the carrier matrix indicated relatively high stability of HA-C18:1 ester bond in bloodstream and complete elimination of the derivative within 72 h. The proposed methodology provides a novel strategy to elucidate the pharmacokinetic behavior of polysaccharide-based drug delivery systems.},
note = {Place: England},
keywords = {*Micelles, Animals, Biodistribution, Chromatography, Doxorubicin, Doxorubicin/*chemistry/pharmacokinetics, Drug Carriers/*chemistry, Drug Liberation, Female, Hyaluronan, Hyaluronic Acid/*chemistry, Liquid, Mice, Molecular Weight, Pharmacokinetics, Polymeric micelles, Tandem Mass Spectrometry, Tissue Distribution},
pubstate = {published},
tppubtype = {article}
}
2014
Jiřík, Radovan; Souček, Karel; Mézl, Martin; Bartoš, Michal; Dražanová, Eva; Dráfi, František; Grossová, Lucie; Kratochvíla, Jiří; Macíček, Ondřej; Nylund, Kim; Hampl, Aleš; Gilja, Odd Helge; Taxt, Torfinn; Starčuk, Zenon Jr
Blind deconvolution in dynamic contrast-enhanced MRI and ultrasound. Journal Article
In: Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference, vol. 2014, pp. 4276–4279, 2014, ISSN: 2694-0604 2375-7477, (Place: United States).
Abstract | Links | BibTeX | Tags: Animals, Cell Line, Contrast Media/*pharmacokinetics, Experimental/diagnostic imaging/metabolism, Gadolinium DTPA/*pharmacokinetics, Humans, Inbred BALB C, Magnetic Resonance Imaging/methods, Mice, Neoplasm Transplantation, Neoplasms, Tissue Distribution, Tumor, Ultrasonography
@article{jirik_blind_2014,
title = {Blind deconvolution in dynamic contrast-enhanced MRI and ultrasound.},
author = {Radovan Jiřík and Karel Souček and Martin Mézl and Michal Bartoš and Eva Dražanová and František Dráfi and Lucie Grossová and Jiří Kratochvíla and Ondřej Macíček and Kim Nylund and Aleš Hampl and Odd Helge Gilja and Torfinn Taxt and Zenon Jr Starčuk},
doi = {10.1109/EMBC.2014.6944569},
issn = {2694-0604 2375-7477},
year = {2014},
date = {2014-01-01},
journal = {Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference},
volume = {2014},
pages = {4276–4279},
abstract = {This paper is focused on quantitative perfusion analysis using MRI and ultrasound. In both MRI and ultrasound, most approaches allow estimation of rate constants (Ktrans, kep for MRI) and indices (AUC, TTP) that are only related to the physiological perfusion parameters of a tissue (e.g. blood flow, vessel permeability) but do not allow their absolute quantification. Recent methods for quantification of these physiological perfusion parameters are shortly reviewed. The main problem of these methods is estimation of the arterial input function (AIF). This paper summarizes and extends the current blind-deconvolution approaches to AIF estimation. The feasibility of these methods is shown on a small preclinical study using both MRI and ultrasound.},
note = {Place: United States},
keywords = {Animals, Cell Line, Contrast Media/*pharmacokinetics, Experimental/diagnostic imaging/metabolism, Gadolinium DTPA/*pharmacokinetics, Humans, Inbred BALB C, Magnetic Resonance Imaging/methods, Mice, Neoplasm Transplantation, Neoplasms, Tissue Distribution, Tumor, Ultrasonography},
pubstate = {published},
tppubtype = {article}
}