2018
Remšík, Ján; Binó, Lucia; Kahounová, Zuzana; Kharaishvili, Gvantsa; Šimecková, Šárka; Fedr, Radek; Kucírková, Tereza; Lenárt, Sára; Muresan, Ximena Maria; Slabáková, Eva; Knopfová, Lucia; Bouchal, Jan; Král, Milan; Beneš, Petr; Soucek, Karel
Trop-2 plasticity is controlled by epithelial-to-mesenchymal transition. Journal Article
In: Carcinogenesis, vol. 39, no. 11, pp. 1411–1418, 2018, ISSN: 1460-2180 0143-3334, (Place: England).
Abstract | Links | BibTeX | Tags: Animals, Antigens, Breast Neoplasms/mortality/*pathology, Cadherins/biosynthesis, Carcinoma/*pathology, CD/biosynthesis, Cell Adhesion Molecules/genetics/*metabolism, Cell Line, Disease Progression, DNA Methylation/genetics, Epithelial Cells/*metabolism, Epithelial-Mesenchymal Transition/physiology, Female, Humans, Inbred BALB C, Male, Mice, Neoplasm/genetics/*metabolism, Prostatic Neoplasms/mortality/*pathology, Tumor, Xenograft Model Antitumor Assays
@article{remsik_trop-2_2018,
title = {Trop-2 plasticity is controlled by epithelial-to-mesenchymal transition.},
author = {Ján Remšík and Lucia Binó and Zuzana Kahounová and Gvantsa Kharaishvili and Šárka Šimecková and Radek Fedr and Tereza Kucírková and Sára Lenárt and Ximena Maria Muresan and Eva Slabáková and Lucia Knopfová and Jan Bouchal and Milan Král and Petr Beneš and Karel Soucek},
doi = {10.1093/carcin/bgy095},
issn = {1460-2180 0143-3334},
year = {2018},
date = {2018-12-01},
journal = {Carcinogenesis},
volume = {39},
number = {11},
pages = {1411–1418},
abstract = {The cell surface glycoprotein Trop-2 is commonly overexpressed in carcinomas and represents an exceptional antigen for targeted therapy. Here, we provide evidence that surface Trop-2 expression is functionally connected with an epithelial phenotype in breast and prostate cell lines and in patient tumor samples. We further show that Trop-2 expression is suppressed epigenetically or through the action of epithelial-to-mesenchymal transition transcription factors and that deregulation of Trop-2 expression is linked with cancer progression and poor patient prognosis. Moreover, our data suggest that the cancer plasticity-driven intratumoral heterogeneity in Trop-2 expression may significantly contribute to response and resistance to therapies targeting Trop-2-expressing cells.},
note = {Place: England},
keywords = {Animals, Antigens, Breast Neoplasms/mortality/*pathology, Cadherins/biosynthesis, Carcinoma/*pathology, CD/biosynthesis, Cell Adhesion Molecules/genetics/*metabolism, Cell Line, Disease Progression, DNA Methylation/genetics, Epithelial Cells/*metabolism, Epithelial-Mesenchymal Transition/physiology, Female, Humans, Inbred BALB C, Male, Mice, Neoplasm/genetics/*metabolism, Prostatic Neoplasms/mortality/*pathology, Tumor, Xenograft Model Antitumor Assays},
pubstate = {published},
tppubtype = {article}
}