2010
Uhlírová, Radka; Horáková, Andrea Harnicarová; Galiová, Gabriela; Legartová, Sona; Matula, Pavel; Fojtová, Miloslava; Varecha, Miroslav; Amrichová, Jana; Vondrácek, Jan; Kozubek, Stanislav; Bártová, Eva
SUV39h- and A-type lamin-dependent telomere nuclear rearrangement. Journal Article
In: Journal of cellular biochemistry, vol. 109, no. 5, pp. 915–926, 2010, ISSN: 1097-4644 0730-2312, (Place: United States).
Abstract | Links | BibTeX | Tags: *Gene Rearrangement, Animals, DNA-Binding Proteins/metabolism, Epigenesis, Fibroblasts/metabolism, Flow Cytometry, Genetic, Humans, Intranuclear Inclusion Bodies/metabolism, Lamin Type A/*metabolism, Methyltransferases/*metabolism, Mice, Protein Transport, rap1 GTP-Binding Proteins/metabolism, Repressor Proteins/*metabolism, Shelterin Complex, Telomerase/metabolism, Telomere-Binding Proteins, Telomere/genetics/*metabolism, Telomeric Repeat Binding Protein 1/metabolism
@article{uhlirova_suv39h-_2010,
title = {SUV39h- and A-type lamin-dependent telomere nuclear rearrangement.},
author = {Radka Uhlírová and Andrea Harnicarová Horáková and Gabriela Galiová and Sona Legartová and Pavel Matula and Miloslava Fojtová and Miroslav Varecha and Jana Amrichová and Jan Vondrácek and Stanislav Kozubek and Eva Bártová},
doi = {10.1002/jcb.22466},
issn = {1097-4644 0730-2312},
year = {2010},
date = {2010-04-01},
journal = {Journal of cellular biochemistry},
volume = {109},
number = {5},
pages = {915–926},
abstract = {Telomeres are specialized chromatin structures that are situated at the end of linear chromosomes and play an important role in cell senescence and immortalization. Here, we investigated whether changes in histone signature influence the nuclear arrangement and positioning of telomeres. Analysis of mouse embryonic fibroblasts revealed that telomeres were organized into specific clusters that partially associated with centromeric clusters. This nuclear arrangement was influenced by deficiency of the histone methyltransferase SUV39h, LMNA deficiency, and the histone deacetylase inhibitor Trichostatin A (TSA). Similarly, nuclear radial distributions of telomeric clusters were preferentially influenced by TSA, which caused relocation of telomeres closer to the nuclear center. Telomeres also co-localized with promyelocytic leukemia bodies (PML). This association was increased by SUV39h deficiency and decreased by LMNA deficiency. These differences could be explained by differing levels of the telomerase subunit, TERT, in SUV39h- and LMNA-deficient fibroblasts. Taken together, our data show that SUV39h and A-type lamins likely play a key role in telomere maintenance and telomere nuclear architecture.},
note = {Place: United States},
keywords = {*Gene Rearrangement, Animals, DNA-Binding Proteins/metabolism, Epigenesis, Fibroblasts/metabolism, Flow Cytometry, Genetic, Humans, Intranuclear Inclusion Bodies/metabolism, Lamin Type A/*metabolism, Methyltransferases/*metabolism, Mice, Protein Transport, rap1 GTP-Binding Proteins/metabolism, Repressor Proteins/*metabolism, Shelterin Complex, Telomerase/metabolism, Telomere-Binding Proteins, Telomere/genetics/*metabolism, Telomeric Repeat Binding Protein 1/metabolism},
pubstate = {published},
tppubtype = {article}
}