2009
Ondrousková, Eva; Slovácková, Jana; Pelková, Vendula; Procházková, Jirina; Soucek, Karel; Benes, Petr; Smarda, Jan
Heavy metals induce phosphorylation of the Bcl-2 protein by Jun N-terminal kinase. Journal Article
In: Biological chemistry, vol. 390, no. 1, pp. 49–58, 2009, ISSN: 1431-6730, (Place: Germany).
Abstract | Links | BibTeX | Tags: Animals, Apoptosis/drug effects, Cell Line, Electrophoresis, Gene Expression Regulation, Heavy/*pharmacology, Humans, JNK Mitogen-Activated Protein Kinases/*metabolism, Metals, Neoplastic/drug effects, Phosphorylation/drug effects, Physiological/drug effects, Post-Translational/drug effects, Protein Processing, Proto-Oncogene Proteins c-bcl-2/*metabolism, Signal Transduction/drug effects, Stress, Tumor, Zinc/pharmacology
@article{ondrouskova_heavy_2009,
title = {Heavy metals induce phosphorylation of the Bcl-2 protein by Jun N-terminal kinase.},
author = {Eva Ondrousková and Jana Slovácková and Vendula Pelková and Jirina Procházková and Karel Soucek and Petr Benes and Jan Smarda},
doi = {10.1515/BC.2009.007},
issn = {1431-6730},
year = {2009},
date = {2009-01-01},
journal = {Biological chemistry},
volume = {390},
number = {1},
pages = {49–58},
abstract = {The Bcl-2 protein is one of the key components of biochemical pathways controlling programmed cell death. The function of this protein can be regulated by posttranslational modifications. Phosphorylation of Bcl-2 has been considered to be significantly associated with cell cycle arrest in the G2/M phase of the cell cycle, and with cell death caused by defects of microtubule dynamics. This study shows that phosphorylation of Bcl-2 can be induced by heavy metals due to activation of the Jun N-terminal kinase pathway that is not linked to the G2/M cell cycle arrest. Furthermore, we demonstrate that hyperphosphorylated Bcl-2 protein is a more potent inhibitor of zinc-induced cell death than its hypophosphorylated mutant form. These data suggest that regulation of Bcl-2 protein function by phosphorylation is an important part of cell responses to stress.},
note = {Place: Germany},
keywords = {Animals, Apoptosis/drug effects, Cell Line, Electrophoresis, Gene Expression Regulation, Heavy/*pharmacology, Humans, JNK Mitogen-Activated Protein Kinases/*metabolism, Metals, Neoplastic/drug effects, Phosphorylation/drug effects, Physiological/drug effects, Post-Translational/drug effects, Protein Processing, Proto-Oncogene Proteins c-bcl-2/*metabolism, Signal Transduction/drug effects, Stress, Tumor, Zinc/pharmacology},
pubstate = {published},
tppubtype = {article}
}