2008
Ondrousková, Eva; Soucek, Karel; Horváth, Viktor; Smarda, Jan
Alternative pathways of programmed cell death are activated in cells with defective caspase-dependent apoptosis. Journal Article
In: Leukemia research, vol. 32, no. 4, pp. 599–609, 2008, ISSN: 0145-2126, (Place: England).
Abstract | Links | BibTeX | Tags: Animals, Antineoplastic Agents/*pharmacology, Apoptosis/*drug effects, Arsenic Trioxide, Arsenicals/pharmacology, Autophagy/*drug effects, Blotting, Camptothecin/pharmacology, Caspases/*metabolism, Cell Line, Cell Transformation, Chickens, Cycloheximide/pharmacology, Fluorescence, Genes, Humans, Microscopy, myb/physiology, Necrosis, Neoplastic/*pathology, Oxides/pharmacology, Signal Transduction/*drug effects, Transformed, U937 Cells/drug effects, Western
@article{ondrouskova_alternative_2008,
title = {Alternative pathways of programmed cell death are activated in cells with defective caspase-dependent apoptosis.},
author = {Eva Ondrousková and Karel Soucek and Viktor Horváth and Jan Smarda},
doi = {10.1016/j.leukres.2007.05.012},
issn = {0145-2126},
year = {2008},
date = {2008-04-01},
journal = {Leukemia research},
volume = {32},
number = {4},
pages = {599–609},
abstract = {Loss of programmed cell death pathways is one of the features of malignancy that complicate the response of cancer cells to a therapy. Activation of alternative cell death pathways offers a promising approach to enhance efficiency of cancer chemotherapy. We analysed programmed cell death pathways of v-myb-transformed BM2 monoblasts induced by arsenic trioxide, cycloheximide and camptothecin with U937 promonocytes as a reference cell line. We show that induced death of BM2 cells is not executed by caspases but rather by alternative cell death pathways. Camptothecin induces the lysosome-dependent cell death, arsenic trioxide induces autophagy, and most of cycloheximide-treated BM2 cells die by necrosis. The fact that alternative cell death pathways can be switched in cells with defects in activation and/or function of caspases suggests that understanding and targeting of these pathways could improve therapy of cancer cells suffering from defective apoptosis.},
note = {Place: England},
keywords = {Animals, Antineoplastic Agents/*pharmacology, Apoptosis/*drug effects, Arsenic Trioxide, Arsenicals/pharmacology, Autophagy/*drug effects, Blotting, Camptothecin/pharmacology, Caspases/*metabolism, Cell Line, Cell Transformation, Chickens, Cycloheximide/pharmacology, Fluorescence, Genes, Humans, Microscopy, myb/physiology, Necrosis, Neoplastic/*pathology, Oxides/pharmacology, Signal Transduction/*drug effects, Transformed, U937 Cells/drug effects, Western},
pubstate = {published},
tppubtype = {article}
}