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2020

Vyhlídalová, Barbora; Krasulová, Kristýna; Pečinková, Petra; Marcalíková, Adéla; Vrzal, Radim; Zemánková, Lenka; Vančo, Jan; Trávníček, Zdeněk; Vondráček, Jan; Karasová, Martina; Mani, Sridhar; Dvořák, Zdeněk

Gut Microbial Catabolites of Tryptophan Are Ligands and Agonists of the Aryl Hydrocarbon Receptor: A Detailed Characterization. Journal Article

In: International journal of molecular sciences, vol. 21, no. 7, 2020, ISSN: 1422-0067, (Place: Switzerland).

Abstract | Links | BibTeX | Tags: *Gastrointestinal Microbiome/drug effects, Animals, Aryl hydrocarbon receptor, Aryl Hydrocarbon/*agonists/*metabolism, Basic Helix-Loop-Helix Transcription Factors/*agonists/*metabolism, Cell Line, Cytochrome P-450 CYP1A1/genetics, Gene Expression, Genes, Genetic, Humans, Indoles, Ligands, Metabolic Networks and Pathways, Mice, Microbiome, Promoter Regions, Protein Binding, Protein Multimerization, Receptors, Reporter, tryptophan, Tryptophan/*metabolism, Tumor

2018

Hýžd'alová, Martina; Pivnicka, Jakub; Zapletal, Ondrej; Vázquez-Gómez, Gerardo; Matthews, Jason; Neca, Jirí; Pencíková, Katerina; Machala, Miroslav; Vondrácek, Jan

Aryl Hydrocarbon Receptor-Dependent Metabolism Plays a Significant Role in Estrogen-Like Effects of Polycyclic Aromatic Hydrocarbons on Cell Proliferation. Journal Article

In: Toxicological sciences : an official journal of the Society of Toxicology, vol. 165, no. 2, pp. 447–461, 2018, ISSN: 1096-0929 1096-6080, (Place: United States).

Abstract | Links | BibTeX | Tags: Aryl Hydrocarbon/genetics/*metabolism, Cell Culture Techniques, Cell Cycle/drug effects/genetics, Cell Proliferation/*drug effects/genetics, Cytochrome P-450 CYP1A1/genetics/metabolism, Cytochrome P-450 CYP1B1/genetics/metabolism, Endocrine Disruptors/metabolism/*toxicity, Estrogen/genetics/metabolism, Gene Expression/drug effects, Gene Knockdown Techniques, Genes, Genetic Vectors, Humans, MCF-7 Cells, Plasmids, Polycyclic Aromatic Hydrocarbons/metabolism/*toxicity, Receptors, Reporter, Transfection

2017

Vondráček, Jan; Pěnčíková, Kateřina; Neča, Jiří; Ciganek, Miroslav; Grycová, Aneta; Dvořák, Zdeněk; Machala, Miroslav

Assessment of the aryl hydrocarbon receptor-mediated activities of polycyclic aromatic hydrocarbons in a human cell-based reporter gene assay. Journal Article

In: Environmental pollution (Barking, Essex : 1987), vol. 220, no. Pt A, pp. 307–316, 2017, ISSN: 1873-6424 0269-7491, (Place: England).

Abstract | Links | BibTeX | Tags: AhR, AhR-mediated activity, Aryl Hydrocarbon/metabolism/*physiology, Basic Helix-Loop-Helix Transcription Factors/metabolism/*physiology, Biological Assay/methods, Carcinogens/toxicity, Cell Line, Environmental Pollutants/*toxicity, Genes, Humans, PAH mixtures, PAHs, Polycyclic Aromatic Hydrocarbons/*toxicity, Receptors, Relative effective potency, Reporter, Vehicle Emissions/toxicity

2006

Davis, Paul A.; Polagruto, John A.; Valacchi, Giuseppe; Phung, Anh; Soucek, Karel; Keen, Carl L.; Gershwin, M. Eric

Effect of apple extracts on NF-kappaB activation in human umbilical vein endothelial cells. Journal Article

In: Experimental biology and medicine (Maywood, N.J.), vol. 231, no. 5, pp. 594–598, 2006, ISSN: 1535-3702 1535-3699, (Place: Switzerland).

Abstract | Links | BibTeX | Tags: Cell Line, Endothelial Cells/cytology/*metabolism, Flavonoids/*metabolism, Genes, Humans, I-kappa B Proteins/metabolism, Malus/*chemistry, NF-kappa B/*metabolism, NF-KappaB Inhibitor alpha, Plant Extracts/*metabolism, Reporter, Umbilical Veins/*cytology