2004
Vaculová, Alena; Hofmanová, Jirina; Soucek, Karel; Andera, Ladislav; Kozubík, Alois
Ethanol acts as a potent agent sensitizing colon cancer cells to the TRAIL-induced apoptosis. Journal Article
In: FEBS letters, vol. 577, no. 1-2, pp. 309–313, 2004, ISSN: 0014-5793, (Place: England).
Abstract | Links | BibTeX | Tags: Apoptosis Regulatory Proteins, Apoptosis/*drug effects/physiology, BH3 Interacting Domain Death Agonist Protein, Blotting, Carrier Proteins/metabolism, Caspases/metabolism, Colonic Neoplasms/enzymology/metabolism/*pathology, Ethanol/*pharmacology, HT29 Cells, Humans, Membrane Glycoproteins/*physiology, Myeloid Cell Leukemia Sequence 1 Protein, Neoplasm Proteins/metabolism, Proto-Oncogene Proteins c-bcl-2/metabolism, TNF-Related Apoptosis-Inducing Ligand, Tumor Necrosis Factor-alpha/*physiology, Western
@article{vaculova_ethanol_2004,
title = {Ethanol acts as a potent agent sensitizing colon cancer cells to the TRAIL-induced apoptosis.},
author = {Alena Vaculová and Jirina Hofmanová and Karel Soucek and Ladislav Andera and Alois Kozubík},
doi = {10.1016/j.febslet.2004.10.013},
issn = {0014-5793},
year = {2004},
date = {2004-11-01},
journal = {FEBS letters},
volume = {577},
number = {1-2},
pages = {309–313},
abstract = {Identification of mechanisms of modulation of the TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis is important for its potential use in anticancer therapy. Ethanol can induce cell death in vitro and in vivo by different signalling pathways. Its effect in combination with death ligands is unknown. We investigated how ethanol modulates the effects of TRAIL in colon cancer cells. After combined TRAIL and ethanol treatment, a potentiation of caspase-8, -9, -3 activation, a proapoptotic Bid protein cleavage, a decrease of mitochondrial membrane potential, a complete poly(ADP)ribose polymerase cleavage, and disappearance of antiapoptotic Mcl-1 protein were demonstrated. Ethanol acts as a potent agent sensitizing colon cancer cells to TRAIL-induced apoptosis.},
note = {Place: England},
keywords = {Apoptosis Regulatory Proteins, Apoptosis/*drug effects/physiology, BH3 Interacting Domain Death Agonist Protein, Blotting, Carrier Proteins/metabolism, Caspases/metabolism, Colonic Neoplasms/enzymology/metabolism/*pathology, Ethanol/*pharmacology, HT29 Cells, Humans, Membrane Glycoproteins/*physiology, Myeloid Cell Leukemia Sequence 1 Protein, Neoplasm Proteins/metabolism, Proto-Oncogene Proteins c-bcl-2/metabolism, TNF-Related Apoptosis-Inducing Ligand, Tumor Necrosis Factor-alpha/*physiology, Western},
pubstate = {published},
tppubtype = {article}
}