2014
Jiřík, Radovan; Souček, Karel; Mézl, Martin; Bartoš, Michal; Dražanová, Eva; Dráfi, František; Grossová, Lucie; Kratochvíla, Jiří; Macíček, Ondřej; Nylund, Kim; Hampl, Aleš; Gilja, Odd Helge; Taxt, Torfinn; Starčuk, Zenon Jr
Blind deconvolution in dynamic contrast-enhanced MRI and ultrasound. Journal Article
In: Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference, vol. 2014, pp. 4276–4279, 2014, ISSN: 2694-0604 2375-7477, (Place: United States).
Abstract | Links | BibTeX | Tags: Animals, Cell Line, Contrast Media/*pharmacokinetics, Experimental/diagnostic imaging/metabolism, Gadolinium DTPA/*pharmacokinetics, Humans, Inbred BALB C, Magnetic Resonance Imaging/methods, Mice, Neoplasm Transplantation, Neoplasms, Tissue Distribution, Tumor, Ultrasonography
@article{jirik_blind_2014,
title = {Blind deconvolution in dynamic contrast-enhanced MRI and ultrasound.},
author = {Radovan Jiřík and Karel Souček and Martin Mézl and Michal Bartoš and Eva Dražanová and František Dráfi and Lucie Grossová and Jiří Kratochvíla and Ondřej Macíček and Kim Nylund and Aleš Hampl and Odd Helge Gilja and Torfinn Taxt and Zenon Jr Starčuk},
doi = {10.1109/EMBC.2014.6944569},
issn = {2694-0604 2375-7477},
year = {2014},
date = {2014-01-01},
journal = {Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference},
volume = {2014},
pages = {4276–4279},
abstract = {This paper is focused on quantitative perfusion analysis using MRI and ultrasound. In both MRI and ultrasound, most approaches allow estimation of rate constants (Ktrans, kep for MRI) and indices (AUC, TTP) that are only related to the physiological perfusion parameters of a tissue (e.g. blood flow, vessel permeability) but do not allow their absolute quantification. Recent methods for quantification of these physiological perfusion parameters are shortly reviewed. The main problem of these methods is estimation of the arterial input function (AIF). This paper summarizes and extends the current blind-deconvolution approaches to AIF estimation. The feasibility of these methods is shown on a small preclinical study using both MRI and ultrasound.},
note = {Place: United States},
keywords = {Animals, Cell Line, Contrast Media/*pharmacokinetics, Experimental/diagnostic imaging/metabolism, Gadolinium DTPA/*pharmacokinetics, Humans, Inbred BALB C, Magnetic Resonance Imaging/methods, Mice, Neoplasm Transplantation, Neoplasms, Tissue Distribution, Tumor, Ultrasonography},
pubstate = {published},
tppubtype = {article}
}
2002
Hoferová, Zuzana; Fedorocko, Peter; Hofmanová, Jirina; Hofer, Michal; Znojil, Vladimír; Minksová, Katerina; Soucek, Karel; Egyed, Alena; Kozubík, Alois
The effect of nonsteroidal antiinflammatory drugs ibuprofen, flurbiprofen, and diclofenac on in vitro and in vivo growth of mouse fibrosarcoma. Journal Article
In: Cancer investigation, vol. 20, no. 4, pp. 490–498, 2002, ISSN: 0735-7907, (Place: England).
Abstract | Links | BibTeX | Tags: Animals, Anti-Inflammatory Agents, Cell Cycle/drug effects, Cell Division/drug effects, Cultured/*drug effects, Diclofenac/*therapeutic use, Experimental, Fibrosarcoma/*drug therapy/pathology, Flurbiprofen/*therapeutic use, Ibuprofen/*therapeutic use, In Vitro Techniques, Inbred C3H, Male, Mice, Neoplasms, Non-Steroidal/*therapeutic use, Survival Rate, Tumor Cells
@article{hoferova_effect_2002,
title = {The effect of nonsteroidal antiinflammatory drugs ibuprofen, flurbiprofen, and diclofenac on in vitro and in vivo growth of mouse fibrosarcoma.},
author = {Zuzana Hoferová and Peter Fedorocko and Jirina Hofmanová and Michal Hofer and Vladimír Znojil and Katerina Minksová and Karel Soucek and Alena Egyed and Alois Kozubík},
doi = {10.1081/cnv-120002149},
issn = {0735-7907},
year = {2002},
date = {2002-01-01},
journal = {Cancer investigation},
volume = {20},
number = {4},
pages = {490–498},
abstract = {For suppression of primary G:5:113 fibrosarcoma growth, three structurally different cyclooxygenase (COX) inhibitors (ibuprofen, flurbiprofen, and diclofenac) were administered intraperitoneally (i.p.) in two regimens starting on day 5 after tumor-cell inoculation. Repeated application of 0.15 mg/mouse/day during 14 consecutive days significantly suppressed the tumor growth and increased the percentage of surviving mice. Similar tendency, however without significant differences, was observed when animals were given 0.5 mg/day for five consecutive days. These results suggest that a time schedule of drug application is important for the therapeutic effect. Suppressive effect of diclofenac and flurbiprofen on tumor growth was also observed under in vitro conditions. We conclude that suppressive effect of these drugs on tumor growth in vivo comprises both direct effects of COX inhibitors on fibrosarcoma cells and indirect effects that are presumably mediated by extratumoral sources. Our findings encourage the use of COX inhibitors in the therapy of fibrosarcoma.},
note = {Place: England},
keywords = {Animals, Anti-Inflammatory Agents, Cell Cycle/drug effects, Cell Division/drug effects, Cultured/*drug effects, Diclofenac/*therapeutic use, Experimental, Fibrosarcoma/*drug therapy/pathology, Flurbiprofen/*therapeutic use, Ibuprofen/*therapeutic use, In Vitro Techniques, Inbred C3H, Male, Mice, Neoplasms, Non-Steroidal/*therapeutic use, Survival Rate, Tumor Cells},
pubstate = {published},
tppubtype = {article}
}