{"id":684,"date":"2024-02-17T22:26:17","date_gmt":"2024-02-17T21:26:17","guid":{"rendered":"https:\/\/lc.ibp.cz\/?p=684"},"modified":"2024-05-19T20:50:16","modified_gmt":"2024-05-19T18:50:16","slug":"prognostic-value-and-multifaceted-roles-of-tetraspanin-cd9-in-cancer","status":"publish","type":"post","link":"https:\/\/lc.ibp.cz\/?p=684","title":{"rendered":"New paper out: Prognostic value and multifaceted roles of tetraspanin CD9 in cancer"},"content":{"rendered":"\n<p><strong>R\u00f3bert Ondru\u0161\u0161ek,&nbsp;Barbora Kvoka\u010dkov\u00e1,&nbsp;Karol\u00edna Kry\u0161tofov\u00e1,&nbsp;Sv\u011btlana Brychtov\u00e1,&nbsp;Karel Sou\u010dek,&nbsp;Jan Bouchal<\/strong><\/p>\n\n\n\n<p>CD9 is a crucial regulator of cell adhesion in the immune system and plays important physiological roles in hematopoiesis, blood coagulation or viral and bacterial infections. It is involved in the transendothelial migration of leukocytes which might also be hijacked by cancer cells during their invasion and metastasis. CD9 is found at the cell surface and the membrane of exosomes affecting cancer progression and therapy resistance. High expression of CD9 is mostly associated with good patients outcome, with a few exceptions. Discordant findings have been reported for breast, ovarian, melanoma, pancreatic and esophageal cancer, which might be related to using different antibodies or inherent cancer heterogeneity. According to <em>in vitro<\/em> and <em>in vivo<\/em> studies, tetraspanin CD9 is not clearly associated with either tumor suppression or promotion. Further mechanistic experiments will elucidate the role of CD9 in particular cancer types and specific conditions.<\/p>\n\n\n\n<p>Volume 13 &#8211; 2023 | <a href=\"https:\/\/doi.org\/10.3389\/fonc.2023.1140738\">https:\/\/doi.org\/10.3389\/fonc.2023.1140738<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>R\u00f3bert Ondru\u0161\u0161ek,&nbsp;Barbora Kvoka\u010dkov\u00e1,&nbsp;Karol\u00edna Kry\u0161tofov\u00e1,&nbsp;Sv\u011btlana Brychtov\u00e1,&nbsp;Karel Sou\u010dek,&nbsp;Jan Bouchal CD9 is a crucial regulator of cell adhesion in the immune system and plays important physiological roles in hematopoiesis, blood coagulation or viral and bacterial infections. It is involved in the transendothelial migration &hellip; <\/p>\n","protected":false},"author":1,"featured_media":685,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[28],"tags":[],"class_list":["post-684","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-publication"],"_links":{"self":[{"href":"https:\/\/lc.ibp.cz\/index.php?rest_route=\/wp\/v2\/posts\/684"}],"collection":[{"href":"https:\/\/lc.ibp.cz\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lc.ibp.cz\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lc.ibp.cz\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/lc.ibp.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=684"}],"version-history":[{"count":3,"href":"https:\/\/lc.ibp.cz\/index.php?rest_route=\/wp\/v2\/posts\/684\/revisions"}],"predecessor-version":[{"id":812,"href":"https:\/\/lc.ibp.cz\/index.php?rest_route=\/wp\/v2\/posts\/684\/revisions\/812"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/lc.ibp.cz\/index.php?rest_route=\/wp\/v2\/media\/685"}],"wp:attachment":[{"href":"https:\/\/lc.ibp.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=684"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lc.ibp.cz\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=684"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lc.ibp.cz\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=684"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}