Month: September 2024

Pre-existing cell subpopulations in primary prostate cancer tumors display surface fingerprints of docetaxel-resistant cells

Stanislav Drápela, Barbora Kvokačková, Eva Slabáková, Anna Kotrbová, Kristína Gömöryová, Radek Fedr, Daniela Kurfürstová, Martin Eliáš, Vladimír Študent Jr, Frederika Lenčéšová, Ganji Sri Ranjani, Vendula Pospíchalová, Vítězslav Bryja, Wytske M van Weerden, Martin Puhr, Zoran Culig, Jan Bouchal, Karel Souček Cell Oncol (Dordr) 2024 Aug 20. DOI: 10.1007/s13402-024-00982-2 Purpose: Docetaxel resistance is a significant obstacle in the treatment of prostate cancer …

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Single-cell profiling of surface glycosphingolipids opens a new dimension for deconvolution of breast cancer intratumoral heterogeneity and phenotypic plasticity

Jiřina Procházková , Radek Fedr , Barbora Hradilová , Barbora Kvokačková , Josef Slavík , Ondrej Kováč , Miroslav Machala , Pavel Fabian , Jiří Navrátil , Simona Kráčalíková , Monika Levková , Petra Ovesná , Jan Bouchal , Karel Souček J Lipid Res, 2024 Jul 30;65(9):100609. DOI: 10.1016/j.jlr.2024.100609 Glycosylated sphingolipids (GSLs) are a diverse group of cellular lipids typically reported as being rare in normal mammary tissue. …

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