The research group, headed by Dr. Karel Souček at the Institute of Biophysics of the Czech Academy of Sciences in Brno, Czech Republic, conducts basic and translational research in the field of cancer biology and invites scientists to apply for …
Read MoreBlog
Two PhD positions in cancer research
Topics: What we offerA 4-year Ph.D. position in cancer research is available under the Animal Physiology, Immunology, and Developmental Biology program at the Faculty of Science, MUNI Brno, Czech Republic. The studentship is funded and includes a part-time grant position. …
Read More
Pre-existing cell subpopulations in primary prostate cancer tumors display surface fingerprints of docetaxel-resistant cells
Stanislav Drápela, Barbora Kvokačková, Eva Slabáková, Anna Kotrbová, Kristína Gömöryová, Radek Fedr, Daniela Kurfürstová, Martin Eliáš, Vladimír Študent Jr, Frederika Lenčéšová, Ganji Sri Ranjani, Vendula Pospíchalová, Vítězslav Bryja, Wytske M van Weerden, Martin Puhr, Zoran Culig, Jan Bouchal, Karel Souček Cell Oncol (Dordr) 2024 Aug 20. DOI: 10.1007/s13402-024-00982-2 Purpose: Docetaxel resistance is a significant obstacle in the treatment of prostate cancer …
Read More
Single-cell profiling of surface glycosphingolipids opens a new dimension for deconvolution of breast cancer intratumoral heterogeneity and phenotypic plasticity
Jiřina Procházková , Radek Fedr , Barbora Hradilová , Barbora Kvokačková , Josef Slavík , Ondrej Kováč , Miroslav Machala , Pavel Fabian , Jiří Navrátil , Simona Kráčalíková , Monika Levková , Petra Ovesná , Jan Bouchal , Karel Souček J Lipid Res, 2024 Jul 30;65(9):100609. DOI: 10.1016/j.jlr.2024.100609 Glycosylated sphingolipids (GSLs) are a diverse group of cellular lipids typically reported as being rare in normal mammary tissue. …
Read More
Aryl hydrocarbon receptor as a drug target in advanced prostate cancer therapy – obstacles and perspectives
Jiřina Procházková, Zuzana Kahounová, Jan Vondráček, Karel Souček Transcription. 2024 Mar 28:1-20 DOI: 10.1080/21541264.2024.2334106 Aryl hydrocarbon receptor (AhR) is a transcription factor that is primarily known as an intracellular sensor of environmental pollution. After five decades, the list of synthetic and toxic chemicals that …
Read More
Transcriptional and phenotypical alterations associated with a gradual benzo[a]pyrene-induced transition of human bronchial epithelial cells into mesenchymal-like cells
Martina Hýžďalová , Jiřina Procházková , Nicol Straková , Kateřina Pěnčíková , Simona Strapáčová , Jana Slováčková , Simona Kajabová , Helena Líbalová , Jan Topinka , Markéta Kabátková , Jan Vondráček , Steen Mollerup , Miroslav Machala Environ Toxicol Pharmacol. 2024 Apr:107:104424 DOI: 10.1016/j.etap.2024.104424
Read More
Revolutionizing Cell Sorting
The Institute of Biophysics of the Czech Academy of Sciences (IBP CAS) welcomed the new cutting-edge spectral flow cytometry sorter from BD Biosciences. This makes IBP CAS the first institution in the Czech Republic and the entire region to adopt …
Read More
New paper out: Prognostic value and multifaceted roles of tetraspanin CD9 in cancer
Róbert Ondruššek, Barbora Kvokačková, Karolína Kryštofová, Světlana Brychtová, Karel Souček, Jan Bouchal CD9 is a crucial regulator of cell adhesion in the immune system and plays important physiological roles in hematopoiesis, blood coagulation or viral and bacterial infections. It is involved in the transendothelial migration …
Read More
New paper out: Circulating tumor cell-derived preclinical models: current status and future perspectives
Zuzana Kahounová, Markéta Pícková, Stanislav Drápela, Jan Bouchal, Eva Szczyrbová, Jiří Navrátil, Karel Souček Despite the advancements made in the diagnosis and treatment of cancer, the stages associated with metastasis remain largely incurable and represent the primary cause of cancer-related deaths. The dissemination of cancer is …
Read More